Results 71 to 80 of about 79,683,097 (270)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Comparison of Papillary Thyroid Microcarcinoma and Carcinoma - Original Article
Endocrinology Research and Practice, 2009 Objective: The aim of this study is to evaluate some preoperative and postoperative clinical and histopathological characteristics of patients with papillary thyroid microcarcinoma (PTMC).
Kamile Gül +8 more
doaj +2 more sources
The Impact of Melatonin on Glucose Homeostasis - Original Article
Endocrinology Research and Practice, 2009 Objective: Melatonin is a pineal product mainly charged with the maintenance of antioxidant conditions in human. This study is performed to identify the short-term effect of melatonin on glucose homeostasis in diabetic patients.
Zeynep Arzu Yeğin +4 more
doaj +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Original data and plot for Fig 19F in the article.
, 2023 Original data and plot for Fig 19F in the article.
Yan-Jia Qiu (15194864) +3 more
core +1 more source
Original article Personality superfactors and healthy behaviors of professional athletes
Current Issues in Personality Psychology, 2014 Background Personality traits seem to be excellent predictors of starting, continuing and discontinuing physical activity. Moreover, they constitute an important determinant of health-seeking behaviors.
Mariusz Lipowski, Łucja Bieleninik
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source