Results 41 to 50 of about 10,207,466 (249)

Constraints on chiral operators in N=2 SCFTs [PDF]

, 2014
Open Access, © The Authors. Article funded by SCOAP3. This article is distributed under the terms of the Creative Commons Attribution License ( CC-BY 4.0 ), which permits any use, distribution and reproduction in any medium, provided the original ...
A Arabi Ardehali, A Gadde, A Hanany, AA Ardehali, AD Shapere, B Assel, C Closset, C Romelsberger, Constantinos Papageorgakis, D Gaiotto, D Gaiotto, D Poland, D Xie, D Xie, DM Hofman, E Witten, F Cachazo, FA Dolan, G Festuccia, GW Moore, H Osborn, J Kinney, J-F Fortin, JA Minahan, JA Minahan, K Kodaira, K Kodaira, M Buican, Matthew Buican, O Aharony, PC Argyres, PC Argyres, PC Argyres, PC Argyres, R Rattazzi, S Benvenuti, S Nawata, Takahiro Nishinaka, VI Arnold, VK Dobrev, VK Dobrev, VK Dobrev, VP Spiridonov   +42 more
core   +5 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

ORIGINAL ARTICLE: Protein Thiols in Essential Hypertension Patients [PDF]

Journal of Krishna Institute of Medical Sciences University, 2012
Background: Essential hypertension is one of the most prevalent diseases of the world and is an unequivocal risk factor for cardiovascular morbidity and mortality.
Jagadish. B. Ingin, Rashmi Sinha, Sharanabasappa M. Awanti   +2 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Original article Unfulfilled parenthood in the eyes of young adults

Health Psychology Report, 2014
Background The goal of the study was to present young adults’ perceptions of the experience of loss of a child at different stages of its prenatal development, as well as the level of declared support for couples after the loss.
Alicja Kalus, Ewa Kiełek-Rataj
doaj   +1 more source

The benefits of applying wound-bed preparation into practice [PDF]

, 2003
Original article can be found at: http://www.journalofwoundcare.com/ Copyright MA HealthcarePeer ...
Fletcher, J.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Bibliometric Qualities of Original Research Published in the Eurasian Journal of Emergency Medicine between the Years 2010-2014

Eurasian Journal of Emergency Medicine, 2016
Aim: Bibliographic work in the Turkish emergency medicine community is very scarce. We aim to improve upon the shortcomings in this area.Materials and Methods: Original research published in the Eurasian Journal of Emergency Medicine (EAJEM) (formerly ...
Mücahit Emet, İlker Akbaş, Abdullah Osman Koçak, Başar Cander, Şahin Aslan   +4 more
doaj   +1 more source