Results 21 to 30 of about 1,438,384 (168)

Baloxavir Marboxil: An Original New Drug against Influenza

Pharmaceuticals, 2021
Baloxavir marboxil is a new drug developed in Japan by Shionogi to treat seasonal flu infection. This cap-dependent endonuclease inhibitor is a prodrug that releases the biologically active baloxavir acid.
François Dufrasne
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Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing

Frontiers in Microbiology
IntroductionGlaesserella parasuis causes Glässer’s disease in pigs, a leading cause of death in swine herds and a major contributor to economic losses in the global swine industry. Although several studies have investigated antimicrobial resistance in G.
Qianwen Ge, Qianwen Ge, Liangxing Fang, Liangxing Fang, Liangxing Fang, Yang Yu, Yang Yu, Yang Yu, Ruanyang Sun, Ruanyang Sun, Xiaoping Liao, Xiaoping Liao, Xiaoping Liao, Peng Zhang, Peng Zhang, Peng Zhang   +15 more
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ESTIMATION OF CLINICAL AND PHARMACOKINETIC EQUIVALENCE OF ORIGINAL AND GENERIC CARVEDILOLS IN PATIENTS WITH HYPERTENSION OF 1-2 GRADES

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study clinical equivalence of original (DilatrendR, ≪Hoffmann-La Roche≫, Switzerland) and of generic (VedicardolR, ≪Synthesis≫, Russia) carvedilols with estimation of their serum level.
E. I. Bambysheva, S. N. Tolpygina, D. F. Guranda, I. E. Koltunov, V. G. Belolipetskaja, S. J. Martsevich   +5 more
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COMPARATIVE EFFICACY AND SAFETY OF HYPOLIPIDEMIC THERAPY WITH GENERIC AND ORIGINAL MEDICINAL PRODUCTS OF SIMVASTATIN

Рациональная фармакотерапия в кардиологии, 2016
Aim. To compare efficacy , safety and pharmacoeconomical characteristics of generic and original medicinal products of simvastatin in achievement of cholesterol and low density lipoprotein target levels. Material and methods.
E. I. Tarlovskaya, Yu. A. Balandina, I. E. Sapozhnikova, N. S. Maksimchuk   +3 more
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STUDY OF CLINICAL EFFICACY OF ORIGINAL AND GENERIC DRUGS OF IVABRADINE IN PATIENTS WITH STABLE ANGINA (СOMPARATIVE STUDY)

Рациональная фармакотерапия в кардиологии, 2018
Aim. To study the therapeutic efficacy and safety of generic drug of ivabradine in comparison with the original drug in patients with stable angina. Material and methods. Patients with stable angina of II-III functional class (n=20) were included into an
S. V. Povetkin, Ju. V. Luneva
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INTERCHANGEABILITY OF MYOCARDIAL CYTOPROTECTORS IN PATIENTS WITH ISCHEMIC HEART DISEASE. DIFFICULT QUESTIONS –SIMPLE SOLUTIONS

Рациональная фармакотерапия в кардиологии, 2015
Indications for myocardial cytoprotector, trimetazidine, in patients with ischemic heart disease are analyzed and justified according to evidence based medicine.
Zh. M. Sizova
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STATIN GENERICS: EFFICACY AND SAFETY RATIO

Рациональная фармакотерапия в кардиологии, 2016
Statin usage for primary and secondary prevention of cardiovascular diseases is focused. Rational choice between original and generic drugs is discussed taking into account efficacy and safety ratio.
V. P. Voronina, A. A. Serazhim, A. V. Zagrebelnyi, S. Yu. Martsevich, S. A. Shalnova   +4 more
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Pharmacokinetic parameters, safety and drug-drug interactions of mirtazapine and tizanidine, combined in the new original drug Dorsumio®

Неврология, нейропсихиатрия, психосоматика, 2023
Objective: to study the pharmacokinetic parameters and safety of Dorsumio® (mirtazapine + tizanidine, extended-release tablets, 15 mg + 6 mg, JSC Valenta Pharm, Russia) taken once by healthy volunteers in comparison with Calixta®, a monocomponent drug ...
A. S. Goncharov, A. V. Grigoriev, A. A. Globenko, I. S. Goncharov, K. A. Muratov, D. V. Yaroshenko, A. A. Sidorova, A. V. Kapashin, O.  V. Kovchan, A. I. Bashkatova, M. A. Pasko   +10 more
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COMPARATIVE EVALUATION OF EFFICACY AND TOLERABILITY OF ORIGINAL AND GENERIC BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION 1-2 GRADE

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study a clinical equivalence of two medications of bisoprolol in patients with arterial hypertension (AH) 1-2 grades.Methods. Efficacy and tolerability of original (Concor, NYCOMED, Merck KGaA) and generic (Bisogamma, WORWAG PHARMA GmbH & Co)
S. N. Tolpygina, E. V. Shilova, S. Y. Martsevich   +2 more
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Pharmacokinetics and Pharmacodynamics of Colistin Combined With Isopropoxy Benzene Guanidine Against mcr-1-Positive Salmonella in an Intestinal Infection Model

Frontiers in Microbiology, 2022
Plasmid-borne colistin resistance mediated by mcr-1 is a growing problem, which poses a serious challenge to the clinical application of colistin for Gram-negative bacterial infections.
Lingli Kong, Lingli Kong, Yixing Lu, Yixing Lu, Liuye Yang, Liuye Yang, Wanying Zhang, Wanying Zhang, Beini Zuo, Beini Zuo, Xianfeng Peng, Zonghua Qin, Miao Li, Zhenling Zeng, Zhenling Zeng, Dongping Zeng, Dongping Zeng   +16 more
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