Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
"What are mortals that you are mindful of them?" A Reading of the Biblical Message about Human Being and Nature from the New Vision of Science and Ecology [PDF]
, 2012 The author integrates the new scientific view of the universe with a rereading of the Genesis creation narratives. He introduces a reading of the human being as Vicar of God in light of \"precomprehension\" offered by science and the ecological crisis ...
Florio, Lucio
core +1 more source
Effects of neutrino oscillation on supernova neutrino: inverted mass hierarchy
, 2002 We study the effects of neutrino oscillation on supernova neutrino in the case of the inverted mass hierarchy ($m_{3} \ll m_{1} < m_{2}$) as well as the normal mass hierarchy ($m_{1} < m_{2} \ll m_{3}$). Numerical analysis using a realistic supernova and
Sato, K., Takahashi, K.
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A primer on the empirics of original sin [PDF]
The empirical literature on "original sin" could be misleading. Eichengreen and Hausmann (1999) defined "original sin" as a liability dollarization bias and as a short term maturity bias. This is a source of concern for all emerging borrowers.
Nader Akmar, Stéphane Colliac
core
Progress Toward an Unthinkable Consummation: Sin and the Evolution of Human Consciousness [PDF]
, 2012 Michael Polanyi has argued that tacit knowing—the consolidation and integration of earlier achievements from which to launch further advances— plays an essential role in evolution.
Layzer, Kate
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Current Account Deficits, Macroeconomic Policy Stance and Governance: An Empirical Investigation [PDF]
This paper empirically investigates the effects of institutional and macroeconomic policy stance variables on current account deficits (CAD). Based on cross-section data for a broad number of developing and industrial countries, the results strongly ...
Erdal Özmen
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Is Large Lepton Mixing Excluded?
, 1993 The original \bnum -(or $\bar{\nu}_{\tau}$-) energy spectrum from the gravitational collapse of a star has a larger average energy than the spectrum for \bnue since the opacity of \bnue exeeds that of \bnum (or $\nu_{\tau}$). Flavor neutrino conversion, \
A. Acker +82 more
core +2 more sources