Results 101 to 110 of about 2,161,493 (288)

A Political Method of Evaluating the Education for All Handicapped Children Act of 1975 and the Several Gaps of Gap Analysis [PDF]

open access: yes, 1985
This project can be seen as a collection of architectural explorations that originate from the concept of misunderstanding. The misunderstanding involves an unconscious transformation that can create something new and unexpected and is therefore an ...
Clune, William H., Van Pelt, Mark H.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Current Account Deficits, Macroeconomic Policy Stance and Governance: An Empirical Investigation [PDF]

open access: yes
This paper empirically investigates the effects of institutional and macroeconomic policy stance variables on current account deficits (CAD). Based on cross-section data for a broad number of developing and industrial countries, the results strongly ...
Erdal Özmen
core  

"What are mortals that you are mindful of them?" A Reading of the Biblical Message about Human Being and Nature from the New Vision of Science and Ecology [PDF]

open access: yes, 2012
The author integrates the new scientific view of the universe with a rereading of the Genesis creation narratives. He introduces a reading of the human being as Vicar of God in light of \"precomprehension\" offered by science and the ecological crisis ...
Florio, Lucio
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

A primer on the empirics of original sin [PDF]

open access: yes
The empirical literature on "original sin" could be misleading. Eichengreen and Hausmann (1999) defined "original sin" as a liability dollarization bias and as a short term maturity bias. This is a source of concern for all emerging borrowers.
Nader Akmar, Stéphane Colliac
core  

Progress Toward an Unthinkable Consummation: Sin and the Evolution of Human Consciousness [PDF]

open access: yes, 2012
Michael Polanyi has argued that tacit knowing—the consolidation and integration of earlier achievements from which to launch further advances— plays an essential role in evolution.
Layzer, Kate
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Is Dollarization the Right Option? Financial Fragility, Original Sin and Fear of Floating [PDF]

open access: yes
This paper focuses on the option of dollarization or euroization for emerging-market economies. There are no “one-size-fits-all” exchange-rate policies for emerging- -market economies; however, there are macroeconomic disadvantages associated with ...
Roman Horváth
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

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