Results 51 to 60 of about 2,161,493 (288)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Original Sin and Judicial Independence: Providing Accountability for Justices [PDF]
, 2009 The independence of the judiciary is an enduring and defining objective of the legal profession. Law depends on judges to observe and enforce it. To secure such virtuous judges, they must be protected from retaliation by those who disapprove their ...
Carrington, Paul D., Cramton, Roger C.
core +3 more sources
The determinants of ‘domestic’ original sin in emerging market economies [PDF]
This paper explains why domestic debt composition in emerging economies is risky. It carries out an analysis of the determinants of ‘domestic’ original sin, which refers to the inability of emerging economies to borrow domestically in local currency, at ...
Mehl, Arnaud, Reynaud, Julien
core +3 more sources
The Formation of the Teaching on Original Sin from the First Through the Fifth Centuries
Богословські роздуми: Східноєвропейський журнал богословʼя, 2016 This article surveys the sources, appearance, development, and establishment of the teaching on original sin as dogma. The material is presented in historical sequence and encompasses the period from the first to the fifth centuries when the church’s ...
Oleg BUDAKOV
doaj
THE THEOLOGICAL PROBLEM WITH EVOLUTION
Zygon, 2021 This article explores hamartiological questions at the interface of evolutionary biology and theology. Such questions include the problem of evil, the possibility of a historical fall, and the meaning of human sinfulness in light of biology.
doaj +2 more sources
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
O ritual do batismo em Portugal na Baixa Idade Média e nos inícios do século XVI
Medievalista, 2014 The ritual of child baptism is still lacking attention in Portuguese historiography. In this article I will focus on its evolution during the Middle Ages, from the moment Saint Augustine of Hippo drew its foundations, until the sixteenth century and the ...
Francisca Pires de Almeida
doaj +1 more source