Results 61 to 70 of about 2,161,493 (288)
Original Sin, Preterition, and its Implications for Evangelization
Perichoresis: The Theological Journal of Emanuel University, 2020 In this paper, I examine the four elements—universal sinfulness, natural sinfulness, inherited sinfulness, and Adamic sinfulness—of the doctrine of original sin in both the Reformed confessions, with particular attention to the Canons of Dort, and the ...
Echeverria Eduardo J.
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Must Original Sin Cause Macroeconomic Damnation? [PDF]
Original sin, coupled with other financial imperfections, causes macroeconomic penance of two kinds: adverse shocks have larger and more persistent effects and monetary policy becomes less effective as a shock absorber. But macroeconomic damnation is not
Andrés Velasco +2 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Criticón, 2009 This study aims to reconstitute a part of the influence exerted by Saint Augustine in Guzmán de Alfarache’s cluster of theological concepts. The major clue allowing the parallelism between the two authors is that Mateo Alemán uses the vital model ...
Philippe Rabaté
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Frank Knight and original sin. [PDF]
Frank Knight was the key person in founding the Chicago school of economics. In this respect he was a seminal figure in the history of twentieth century economics. Yet, few current economists know much about Knight.
Robert H. Nelson
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Original Sin of Writing and Reading
ReligionsThis study examines the possible points of connection between crime and reading on the basis of genre-typical roles and motifs in detective fiction. I aim to identify characteristic reading methods, strategies, locations, events, and professions with ...
Kristián Benyovszky
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