Results 101 to 110 of about 2,084 (261)
, 2009 One of the most persistent criticisms of originalism-and also one of the most powerful-is that originalism is not a viable interpretative methodology because of the tremendous technological, social, cultural, religious, and moral change that has occurred
Strang, Lee J.
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Originalism: A Critical Introduction
, 2013 The theory of originalism is now well into its second wave. Originalism first came to prominence in the 1970s and 1980s as conservative critics reacted to the decisions of the Warren Court, and the Reagan Administration embraced originalism as a ...
Whittington, Keith E.
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Originalism, Precedent, and Candor [PDF]
, 2005 Part of Symposium: "Can Originalism be Reconciled with Precedent? A Symposium on Stare Decisis"Strauss, David A.. (2005). Originalism, Precedent, and Candor.
Strauss, David A.
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The Origin of the Elements [PDF]
Scientific American, 1956 It is my privilege to begin our consideration of the history of the universe during this first scientific session of the Academy Centennial with a discussion of the origin of the elements of which the matter of the universe is constituted. The question of the origin of the elements and their numerous isotopes is the modern expression of one of the most
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Balkinization of Originalism
, 2012 This Article suggests that, with the publication of Jack Balkin\u27s Living Originalism, we are witnessing the Balkanization of originalism (when originalism splits into warring camps) along with the Balkinization of originalism (when even Balkin ...
Fleming, James E.
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