Results 91 to 100 of about 2,084 (261)
Argumentation and explanation in the law. [PDF]
Front Artif Intell, 2023 Rotolo A, Sartor G.
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
, 2021 The author of this Article uses the nondelegation debate as a lens to see whether originalism as it is currently practiced is a useful or dangerous tool of constitutional interpretation.
Eggert, Kurt
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, 2010 Originalism is in ascendance. Both in judicial opinions and in the legal academy, originalist methods of constitutional interpretation are increasingly prominent. This essay nevertheless makes what may seem a claim – originalism is useless.
Rosenthal, Lawrence
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2019 In this Review of Unwritten, we will make three points. First, we will describe Amar's method in revealing an unwritten Constitution. We will use women's rights as an example of a gap in the written Constitution that Amar corrects with a variety of ...
Delahunty, Robert J., Yoo, John
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
, 2009 Much has been written about originalism - the idea that the Constitution should be interpreted according to its original meaning. This Article goes beyond previous works by asserting that originalism may be nearing its demise.
Shaman, Jeffrey +2 more
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Originalism, Official History, and Perspectives versus Methodologies
, 2023 This paper addresses a well-worn topic: originalism, the theory that judges should interpret the Constitution in a manner consistent with the intent of its framers. I am interested in the real-world effects of originalism.
Hylton, Keith N.
core +2 more sources