Results 81 to 90 of about 2,084 (261)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
UNRAVELING THE THREADS OF CONSTITUTIONAL INTERPRETATION: EXPLORING KEY PRINCIPLES
Хабаршы. Заң сериясыThe analysis looks at how each of these principles influences the process of constitutional interpretation and how they may conflict or complement each other.
Д.Б. Махамбетсалиев +1 more
doaj +1 more source
, 2009 For all its proponents' claims of its necessity as a means of constraining judges, originalism is remarkably unpopular outside the United States. Recommended responses to judicial activism in other countries more typically take the form of minimalism or textualism. This Article considers why.
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Palaeontology, 2012 Abstract: Palaeontologists have always had something to say about the origins of biodiversity. However, until recently, most of what they had to say was somewhat speculative. Following the inspirational suggestions by Simpson in the 1940s, the American ‘paleobiological revolution’ of the 1970s encouraged palaeontologists to think numerically and in ...
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Constitutional originalism ::a debate /
, 2017 Constitutional originalism is the theory that fidelity to the original understanding of the US Constitution should constrain contemporary judges.
Solum, Lawrence,, Bennett, Robert W.
core +1 more source
Nature, 1946 IN articles in Nature1, I have set out the conclusion that a great part of human speech originated in the speaking organs' unconscious imitation of the gestures of tne human body, especially the hands. The three articles dealt only with Ide. and Hebrew (as representative of the Semitic group).
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source