Results 81 to 90 of about 3,578 (249)
The Great Depression and Canada's Major Originalist Decade
Osgoode Hall Law JournalFew periods of Canadian history have been as momentous or terrible as the Great Depression. The Dominion and provincial governments’ inability to combat financial and environmental catastrophe led many Canadians to openly question the appropriateness of ...
Preston Jordan Lim
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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The Official Story of the Law. [PDF]
Oxf J Leg Stud, 2023 Baude W, Sachs SE.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
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Frontiers in Political ScienceIntroductionThe Constitution of any nation, which embodies aspirations for a democratic republic and strives to replace oppressive structures with liberal democratic ideals, envisions a criminal justice system that is not only humane, equitable, and just
Harleen Kaur +2 more
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Fit, Justification, and Fidelity in Constitutional Interpretation
Problema: Anuario de Filosofía y Teoría del Derecho, 2015 Dworkin desarrolló el famoso argumento de que la mejor interpretación de una Constitución se debe ajustar y justificar el material jurídico, por ejemplo, el texto, el significado original y los precedentes.
James E. Fleming
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
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