Results 61 to 70 of about 3,578 (249)
On the Origin of Leprosy [PDF]
Science, 2005 Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae . This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics,
Monot, Marc +21 more
openaire +5 more sources
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
European Papers(Series Information) European Papers - A Journal on Law and Integration, 2026 11(2), 1387–1416 | Article | (Table of Contents) 1. Simple as it is? – 1.1. Analysis of drafting elements. – 1.2. Interpretative and systematic understanding. – 2.
Roberto Cisotta
doaj +1 more source
On the Origin of Sequence [PDF]
Life, 2015 Three aspects which make planet Earth special, and which must be taken in consideration with respect to the emergence of peptides, are the mineralogical composition, the Moon which is in the same size class, and the triple environment consisting of ocean, atmosphere, and continent.
openaire +4 more sources
Soft Matter, 2022 Kauffman proposed that living systems exist in a solid-like regime poised near the brink of chaos. Here we ask if this abstact notion might be realized in the jammed cellular collective poised near the brink of unjamming.
openaire +3 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
On the Origin of Metadata [PDF]
Information, 2012 Metadata has been around and has evolved for centuries, albeit not recognized as such. Medieval manuscripts typically had illuminations at the start of each chapter, being both a kind of signature for the author writing the script and a pictorial chapter anchor for the illiterates at the time.
Mannens, Erik +6 more
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Theory of Constitutional Interpretation in Activity of U.S. Supreme Court
RUDN Journal of Law, 2017 Trying situation in U.S law system characterized of searching responsibility of U.S. Supreme Court for modern signs of crisis. The role of interpretation strengthening continuously and are research’s object. The value of this theme is in investigation of
Vladimir N Safonov
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source