Results 41 to 50 of about 2,084 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Specyfika konstytucjonalizmu stanowego w USA

open access: yesPoliteja, 2017
Peculiarities of American State Constitutionalism The article summarizes major peculiarities of American state constitutionalism, understood as a set of general principles governing form, legal nature, and content of state constitutions.
Dariusz Stolicki
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Profiling originalism

open access: yes, 2011
Originalism is a subject of both legal and political discourse, invoked not just in law review scholarship but also in popular media and public discussion. This Essay presents the first empirical study of public attitudes about originalism.
Persily, Nathaniel A.   +3 more
core   +2 more sources

Originalism as Fable (Reviewing Eric Segall, Originalism as Faith)

open access: yes, 2018
Eric Segall\u27s Originalism as Faith provides both a history of the originalist movement in constitutional interpretation and a critique of that movement from the perspective of legal realism. This Review Article summarizes Segall\u27s main argument: as
Telman, Jeremy
core   +3 more sources

Antonin Scalia’s Textualism in philosophy, theology, and judicial interpretation of the Constitution

open access: yesUtrecht Law Review, 2007
Textualism or Originalism, as defended by Justice Antonin Scalia of the U.S. Supreme Court, is a normative doctrine of method according to which the judicial interpretation of statutes and of the Constitution should aim at establishing the original ...
Herman Philipse
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

BALKIN, Jack M.: Living originalism

open access: yesČasopis pro Právní Vědu a Praxi, 2015
Recenze publikace - BALKIN, Jack M.: Living originalism London, Cambridge, 2011, 474 s.
Michal Malaník
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Territoires autochtones et revendications au Canada. Les incohérences du discours originaliste en anthropologie et en droit

open access: yesDroit et Cultures
In Canada, aboriginal rights are protected by the constitution. These rights take their source in pre-colonial Indigenous cultural and legal systems. They can be mobilized by demonstrating the continuity of an Indigenous cultural practice that existed ...
Leila Inksetter
doaj   +1 more source

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