Results 251 to 260 of about 1,434,799 (290)
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
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FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
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Macromolecules and the Origin of Life
Origins of Life, 1974From our knowledge of present day organisms, it is hard to imagine a living assembly, even at its most primitive stage, without macromolecules. In order to look for the macromolecules which possibly participated in the assembly of the primitive organisms, the reaction and formation of polymers in HCN under irradiation of ultraviolet ray of 184.9 nm ...
H, Noda, H, Mizutani, H, Okihana
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GHOSTS IN THE ORIGINS OF LIFE?
International Journal of Bifurcation and Chaos, 2006The so-called bottleneck or ghost can appear after a saddle-node bifurcation, leaving a region in phase space by which the flow is attracted although no fixed points are present. Such ghosts, displayed by some dynamical systems, actually cause a delay of the flow.
Josep Sardanyés, Ricard V. Solé
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Angewandte Chemie International Edition in English, 1973
AbstractThe theory of the evolution of the species, which is today widely accepted, requires a starting point. It is postulated that the biological starting point could have emerged only if chemical evolution had preceded it. Experiments are described which show the formation of organic substances from inorganic gases under conditions which prevailed ...
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AbstractThe theory of the evolution of the species, which is today widely accepted, requires a starting point. It is postulated that the biological starting point could have emerged only if chemical evolution had preceded it. Experiments are described which show the formation of organic substances from inorganic gases under conditions which prevailed ...
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Origins of Life and Evolution of Biospheres, 2005
Sea ice occurs abundantly at the polar caps of the Earth and, probably, of many other planets. Its static and dynamic properties that may be important for prebiotic and early biotic reactions are described. It concentrates substrates and has many features that are important for catalytical actions. We propose that it provided optimal conditions for the
Trinks, H. +2 more
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Sea ice occurs abundantly at the polar caps of the Earth and, probably, of many other planets. Its static and dynamic properties that may be important for prebiotic and early biotic reactions are described. It concentrates substrates and has many features that are important for catalytical actions. We propose that it provided optimal conditions for the
Trinks, H. +2 more
openaire +3 more sources
The origins of research into the origins of life
Endeavour, 2006Most scientists at the end of the 19th and the beginning of the 20th century chose to ignore the question of the origin of life on Earth, regarding it as too mysterious and complex to handle. Yet, in the early 1950s an experimental field devoted to the study of the problem made its first steps. The pioneering theories of several scientists in the first
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Hypercycles and the origin of life
Nature, 1979Perhaps the most difficult step to explain in the origin of life is that from the replication of molecules (RNA for example) in the absence of specific proteins, to the appearance of polymerases and other proteins involved in the replication of RNA and themselves coded for by that RNA.
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International Journal of Astrobiology, 2007
AbstractMechanisms of interstellar panspermia have recently been identified whereby life, wherever it has originated, will disperse throughout the habitable zone of the Galaxy within a few billion years. This re-opens the question of where life originated.
W.M. Napier +2 more
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AbstractMechanisms of interstellar panspermia have recently been identified whereby life, wherever it has originated, will disperse throughout the habitable zone of the Galaxy within a few billion years. This re-opens the question of where life originated.
W.M. Napier +2 more
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Origins of Life, 1977
Random chemical reactions in the Earth's primitive hydrosphere could have generated no more than 200 bits of information, whereas the first Darwinian organism must have encoded about a million bits, and therefore could not have arisen by chance. This information gap is bridged by separating reproduction from organism, and postulating a reproductive ...
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Random chemical reactions in the Earth's primitive hydrosphere could have generated no more than 200 bits of information, whereas the first Darwinian organism must have encoded about a million bits, and therefore could not have arisen by chance. This information gap is bridged by separating reproduction from organism, and postulating a reproductive ...
openaire +2 more sources