Results 191 to 200 of about 185,594 (307)

Submerged geomorphic record of Quaternary palaeoshorelines: terraces and clinothems along a shelf‐edge in the Žirje Archipelago, Adriatic Sea

open access: yesBoreas, EarlyView.
Numerous studies have shown that during the Quaternary there were substantial fluctuations in sea level in response to glacial–interglacial climate variability, reaching lowstand positions up to 134 m below the present sea level (b.s.l.). These fluctuations have had a strong influence on the morphology of shallow shelf seas, which preserve evidence of ...
Ozren Hasan   +7 more
wiley   +1 more source

Artificial intelligence‐based statistical modeling delineates architectural distortion in focal cortical dysplasia

open access: yesBrain Pathology, EarlyView.
Histopathological identification of subtle cortical architectural abnormalities in focal cortical dysplasia (FCD) resections remains challenging. We investigated if artificial intelligence (AI)‐based morphometric and spatial analysis of NeuN‐stained cortical sections could detect neuronal architectural disorganization in epilepsy resections, including ...
Andrew Cannon   +9 more
wiley   +1 more source

A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig   +7 more
wiley   +1 more source

The Americas are not on track to end TB: tuberculosis incidence analysis under the 2025 WHO goals. [PDF]

open access: yesFront Public Health
Rodríguez-Pazmiño ÁS   +6 more
europepmc   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof   +8 more
wiley   +1 more source

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