Discovery of a cryptic aminoacidic triad involved in the temperature adaptation of GH1 enzymes
Cold‐active enzymes retain high catalytic activity at low temperatures but are characterized by thermal instability, a behavior not fully understood. Comparison between a cold‐active GH1 and its mesophilic counterparts highlights the role of a three‐residue motif (W‐M‐F) in conferring structural stability to a mesophilic GH1.
Stefania Digiovanni +5 more
wiley +1 more source
PEG400 regulates Falcipain 2 activity through an allosteric mechanism
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath +2 more
wiley +1 more source
'There's No Improvement. I'm Still Bedridden': Recovery After Hospital Admission for Low Back Pain and Alignment With Patient Expectations. [PDF]
Orlando JF +4 more
europepmc +1 more source
In Vitro Assessment of 3T MRI Effects on Non–3T‐Compatible Cardiac Implantable Electronic Devices
ABSTRACT Background The safety of cardiac implantable electronic devices (CIEDs) during 3‐Tesla (3T) MRI remains uncertain, particularly for devices not designed for 3T use. We experimentally evaluated 3T MRI effects on 3T‐compatible and non–3T‐compatible CIEDs.
Yu Fukuoka +10 more
wiley +1 more source
Disseminated Histoplasmosis and Aortic Valve Infective Endocarditis in a Patient With Recent Aortobifemoral Bypass. [PDF]
Behjatnia H +6 more
europepmc +1 more source
Randomly Albright: The End of Judge Shopping in the Western District of Texas?
ABSTRACT Because judges exercise discretion in how they handle and decide cases, heterogeneity across judges can affect case outcomes and, thus, preferences among litigants for particular judges. However, selection obscures the causal mechanisms that drive these preferences.
Christian Helmers +2 more
wiley +1 more source
Correction: Characterizing, protocolizing, and scaling up local adjunctive interventions and implementation strategies to enhance the reach of HIV-prevention and mental health/substance use treatments: a study protocol. [PDF]
Harkness A +18 more
europepmc +1 more source
Abstract Catfishes of the subfamily Trichomycterinae comprise the most diverse fish group with species adapted to live in Neotropical caves, but past evolutionary scenarios that have driven the origin of these troglobitic species remain unknown. We herein investigate the phylogenetic position of the cave‐restricted Trichomycterus rubbioli, endemic to ...
Wilson J. E. M. Costa +6 more
wiley +1 more source

