Results 91 to 100 of about 11,081 (214)

Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes

Journal of Obesity, 2011
Objective. Determine the impact of Orlistat-induced weight loss on metabolic profile and cardiovascular function in severely obese patients with type 2 diabetes. Methods.
Julie Martin, Carmen Paquette, Simon Marceau, Frédéric-Simon Hould, Stéfane Lebel, Serge Simard, Jean-Gaston Dumesnil, Paul Poirier   +7 more
doaj   +1 more source

In vitro examination of the effect of orlistat on the ability of the faecal microbiota to utilize dietary lipids

, 2009
Orlistat is an anti-obesity treatment with which several gastrointestinal (GI) side-effects are commonly associated in the initial stages of therapy. There is no physiological explanation as to why two-thirds of those who take the drug experience one or ...
Hoyles, L.
core  

Ferroptosis in breast cancer: From adipocyte–immune–iron regulation to therapeutic application

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Ferroptosis in breast cancer is regulated by an integrated adipocyte–immune–iron network rather than by tumour‐intrinsic pathways alone. Adipocyte‐derived lipid substrates and redox metabolites, immune‐cell‐mediated cytokine signalling and iron‐dependent oxidative stress collectively shape a dynamic ferroptosis ecosystem that can shift tumours towards ...
Juan Sun, Yang Qu, Ru Yao, Yidong Zhou
wiley   +1 more source

Clinical and economic considerations of antiobesity treatment: a review of orlistat

ClinicoEconomics and Outcomes Research, 2010
Armineh ZohrabianDivision of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USAAbstract: The objective of this study was to review the current knowledge about the use of orlistat from clinical and economic ...
Armineh Zohrabian
doaj  

GC–MS‐Based Metabolomic Insights Into Fermentation‐Induced Bioactive Compounds and Metabolic Health‐Related Activities of White Corn Steep Liquor

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Time‐dependent fermentation caused dynamic changes in the bioactive constituents of white corn steep liquor and improved its antioxidant, antidiabetic, and antiobesogenic activities in vitro. ABSTRACT The present study investigated the effect of crude fermentation on white corn steep liquor and its bioactive constituents in the management of metabolic ...
Lemohang Gumenku, Ochuko L. Erukainure, S'thandiwe N. Magwaza, Almahi I. Mohamed, Md. Shahidul Islam, Ademola O. Olaniran   +5 more
wiley   +1 more source

Orlistat for the treatment of antipsychotic-induced weight gain: an eight-week multicenter, randomized, placebo-controlled, double-blind trial

Lipids in Health and Disease
Background Weight gain and metabolic disorders are commonly induced by antipsychotics. Orlistat is a lipase inhibitor used for weight control. The effect of orlistat on weight gain and metabolic disturbances in people (especially women) treated with ...
Peng Xie, Tiannan Shao, Yujun Long, Weiwei Xie, Yangjun Liu, Ye Yang, Yuyan Huang, Renrong Wu, Qijian Deng, Hui Tang   +9 more
doaj   +1 more source

Orlistat (Xénical)

, 1999
Orlistat, a potent inhibitor of the pancreatic and intestinal lipases, is the first member of a new therapeutic class approved for the treatment of obesity.
Sternon, J., Crenier, Laurent
core  

Bile Acids as Selective Gatekeepers of Dietary Lipid Absorption: Mechanistic Insights and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Their work provides evidence in murine models that the bile acid pool may function as a tunable filter whose selectivity for different fatty acids depends on bile acid concentration and composition. This framework suggests a selective decoupling of the absorption of excessive saturated fatty acids (SFAs) from that of beneficial polyunsaturated
Hao Wang, Yue Yang, Yulong Zhang, Yinling Li, Xuemei Ma, Haitao Wang   +5 more
wiley   +1 more source

Effect of preconceptional orlistat treatment on in-vitro fertilization outcome in overweight/obese women: study protocol for a randomized controlled trial

Trials, 2018
Background Obese women have fewer oocytes retrieved, an increased cancelation rate, a higher miscarriage rate, and a lower live birth rate after assisted reproductive technology (ART) treatment compared with women with normal weight.
Jing Li, Ze Wang, Daimin Wei, Hong Liu, Jiangtao Zhang, Jianfeng Wang, Yuhua Shi, Zi-Jiang Chen   +7 more
doaj   +1 more source

Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase

, 2015
Fatty acid synthase (FASN), the sole protein capable of de novo synthesis of free fatty acids, is overexpressed in a wide variety of human cancers and is associated with poor prognosis and aggressiveness of these cancers.
Valerie E. Fako (1337565), Jing-Yuan Liu (1319196), Jian-Ting Zhang (8250)   +2 more
core   +1 more source