Results 71 to 80 of about 12,566 (192)

Vitamin D: Physiology, Pharmacology and Clinical Evidence for Supplementation—A Narrative Review

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Vitamin D is a nutrient and prohormone obtained from diet and supplements and synthesized in the skin. It is essential for calcium and phosphate homeostasis and skeletal health and influences multiple extra‐skeletal processes, yet deficiency remains common worldwide.
Jyrki K. Virtanen
wiley   +1 more source

Effect of Orlistat in Obese Patients with Binge Eating Disorder

, 2005
OBJECTIVE: Binge eating disorder represents a significant public health problem, with up to 50% of weight loss program participants displaying this disorder. In previous studies with orlistat, patients with binge eating disorder were excluded.
Frank Habicht, Habicht, F., Yves Schutz, Kammer, A., Alain Golay, Chabloz, M., Jean‐Pierre Gachoud, Anne Kammer, Mireille Chabloz, Laurent-Jaccard, A., Gachoud, J.P., Schutz, Y., Golay, A., Anne Laurent‐Jaccard, Kammer A, Laurent-Jaccard A, Habicht F, Schutz Y, Gachoud JP, Golay A, Chabloz M   +20 more
core   +1 more source

Orlistat facilitates immunotherapy via AKT-FOXO3a-FOXM1-mediated PD-L1 suppression

Journal for ImmunoTherapy of Cancer
Background The immunotherapy targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death ligand-1 (PD-L1) has achieved significant breakthroughs, but further improvements are still needed in cancer treatment.Methods We ...
Jie Li, Shiming Yang, Liting Wang, Xiaoyan Zhao, Changjiang Hu, Qingyun Tang, Lianhua Zhang, Shuo Zeng, Qiyu Bao, Weichao Hu, Lijiao He, Guiping Huang, Yunyi Liu   +12 more
doaj   +1 more source

Effect of orlistat on obese women with polycystic ovary syndrome

Journal of Bio-X Research, 2018
. Polycystic ovary syndrome (PCOS) is a common gynecological endocrine syndrome characterized by metabolic abnormality and reproductive dysfunction, including ovulation abnormality, hyperandrogenism and polycystic ovarian manifestations.
Qi Jiang, Yuhua Shi
doaj   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, Volume 183, Issue 22, Page 6656-6662, November 2026.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients

, 2010
Our study wants to evaluate the effects of one year treatment with orlistat plus L-carnitine compared to orlistat alone on body weight, glycemic and lipid control, and insulin resistance state in type 2 diabetic patients.
FERRARI, ILARIA, Palumbo I, Sabrina Randazzo, Arrigo F.G. Cicero, Angela D’Angelo, D'ANGELO, ANGELA, Fogari E, DEROSA, GIUSEPPE, Ilaria Palumbo, Ilaria Ferrari, Cicero AFG, Pamela Maffioli, Giuseppe Derosa, MAFFIOLI, PAMELA, Randazzo S, Elena Fogari, Ferrari I, Derosa G, CICERO, ARRIGO FRANCESCO GIUSEPPE, Maffioli P, D'Angelo A   +20 more
core   +2 more sources

Effects of a novel weight-loss combination product containing orlistat and resveratrol on obesity: A multicenter randomized controlled study (EC-FIT)

Endocrine and Metabolic Science
Background: Orlistat, a weight loss medication, is often less effective due to poor adherence to the dietary and exercise recommendations. However, its effectiveness is often compromised by poor adherence to recommended lifestyle changes and side effects
Khin Maung Win, Tint Swe Latt, Aung Hlaing Bwa, Khin Maung Aye, Kyaw Soe Tun, Hardik Gandhi   +5 more
doaj   +1 more source

Tirzepatide Persistence and Associated Changes in Clinical Outcomes in US Adults With Obesity or Overweight: A 6‐Month Claims Database Analysis

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9966-9979, November 2026.
ABSTRACT Aims Tirzepatide is a once‐weekly glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) approved in the US for the treatment of Type 2 diabetes (T2D), weight loss and obstructive sleep apnoea. This study aimed to assess the utilisation and effectiveness of tirzepatide among individuals in a large ...
Theresa Hunter Gibble, Malvika Venkataraman, Donna Mojdami, Carlos Vallarino, Grace Stockbower, Michael Grabner, Mythili Ananth, Karishma Desai   +7 more
wiley   +1 more source

The Effect of Behavioral Sleep Interventions on Measures of Obesity, Dietary Intake and Physical Activity in Adults With Poor Sleep Health: A Systematic Review, Meta‐Analysis and Meta‐Regression Analysis

Obesity Reviews, Volume 27, Issue 11, November 2026.
ABSTRACT Background As poor sleep negatively impacts on adiposity, there is interest in examining whether improving sleep can improve adiposity markers. We reviewed studies aimed at improving sleep using (1) cognitive behavioral therapy for insomnia (CBT‐I) and/or sleep hygiene and (2) sleep extension on adiposity markers, dietary intake, and physical ...
Samiul A. Mostafa, Pushpa Singh, Feaz Babwah, Wasim Hanif, George Balanos, Krishnarajah Nirantharakumar, Jason G. Ellis, Abd A. Tahrani   +7 more
wiley   +1 more source

Commentary on prevention a possible drug-drug interaction: Is concurrent administration of orlistat and pioglitazone increase the risk of durg-induced hepatotoxicity?

International Journal of Preventive Medicine, 2015
Background: Drug-drug interactions (DDIs) are an emerging threat to public health and are difficult to detect. To prevent DDIs and their burden, the possible DDIs should be kept in mind.
Marjan Emzhik, Parvaneh Rahimi-Moghaddam, Soltan Ahmad Ebrahimi, Fariborz Keyhanfar, Ashraf Sadat Moazzam   +4 more
doaj   +1 more source