Results 61 to 70 of about 8,884 (175)

Positioning Incretin‐Based and Next‐Generation Obesity Management Medications: A Methodological Framework for a Series of Systematic Reviews and Network Meta‐Analyses

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7768-7778, September 2026.
ABSTRACT Background The obesity pharmacotherapy landscape is evolving rapidly, with several approved incretin‐based therapies and an expanding pipeline of investigational compounds targeting multiple metabolic pathways. Conventional evidence syntheses often struggle to accommodate differences in dose selection, treatment duration and stage of clinical ...
Matteo Monami, Benedetta Ragghianti, Edoardo Mannucci   +2 more
wiley   +1 more source

Therapeutic Potential of Water‐Based Anatolian Propolis Extract Against CAF Diet‐Induced Obesity and Its Metabolic Complications

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Water‐based Anatolian propolis extract attenuates CAF diet‐induced obesity‐related metabolic disturbances by improving dyslipidemia, hepatic injury, adipokine imbalance, and inflammatory status in C57BL/6 mice. ABSTRACT This study investigates the anti‐obesity effects of water‐based Anatolian propolis extract in mice with a cafeteria diet‐induced ...
Mehmet Kemal, Elif Şahin, Ali Kulaber, Sevil Kör, Ahmet Alver, Engin Yenilmez, Sevgi Kolaylı   +6 more
wiley   +1 more source

Evaluation of efficacy and safety of orlistat in obese patients

Indian Journal of Endocrinology and Metabolism, 2011
Context: Rapidly rising prevalence of obesity is alarming. Obesity predisposes to co-morbidities like hypertension, type 2 diabetes mellitus, dyslipidemias, thus substantially rising healthcare expenditure. Lifestyle modifications alone have very limited
Suyog S Jain, Sunita J Ramanand, Jaiprakash B Ramanand, Pramod B Akat, Milind H Patwardhan, Sachin R Joshi   +5 more
doaj   +1 more source

Dose‐Dependent Anti‐Obesity and Protective Effects of Chia (Salvia hispanica L.) Seed Oil Against Hematological and Hepatorenal Dysfunction in High‐Fat Diet–Fed Mice

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Chia seed oil ameliorates obesity, dyslipidemia, and hepatorenal dysfunction in high‐fat diet–fed mice. ABSTRACT Chia seeds (Salvia hispanica L.) are recognized as a functional food with a nutrient‐dense profile and health‐promoting properties. In the present study, hexane‐extracted chia seed oil was investigated for anti‐obesity, hematoprotective, and
Sabbya Sachi, Mst. Prianka Jahan, Sree Alok Kumar, Mahmudul Hasan Sikder, Md. Zahorul Islam   +4 more
wiley   +1 more source

Commentary on prevention a possible drug-drug interaction: Is concurrent administration of orlistat and pioglitazone increase the risk of durg-induced hepatotoxicity?

International Journal of Preventive Medicine, 2015
Background: Drug-drug interactions (DDIs) are an emerging threat to public health and are difficult to detect. To prevent DDIs and their burden, the possible DDIs should be kept in mind.
Marjan Emzhik, Parvaneh Rahimi-Moghaddam, Soltan Ahmad Ebrahimi, Fariborz Keyhanfar, Ashraf Sadat Moazzam   +4 more
doaj   +1 more source

ATF4/SCO2 Inhibits Ferroptosis in Lung Cancer Through Activating the MAPK Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ATF4 activates the transcription of SCO2 to increase SCO2 expression that further stimulates p38/ERK1 signals in MAPK pathway, ultimately promoting proliferation and migration while inhibiting apoptosis and ferroptosis of lung cancer cells. ABSTRACT Ferroptosis is a specific cell death form resulting from the iron‐dependent lipid peroxidation ...
Liang Yu, Sheng Zhang, Jinxi He, Bo Ma, Xuyang Song, Rui Qiu, Bo Yu   +6 more
wiley   +1 more source

BODY‐Q‐7D Measures Consensus‐Based Patient‐Reported Outcomes for the Management of Obesity Treatment

Obesity, Volume 34, Issue 8, Page 1600-1612, August 2026.
ABSTRACT Objective A global multidisciplinary consensus initiative identified eight patient‐reported outcome domains important in obesity care: self‐esteem; physical, mental, and social health; eating; stigma; body image; and excess skin. Several of these domains are not represented in generic preference‐based measures typically used in weight loss ...
Anne F. Klassen, Charlene Rae, Claire E. E. de Vries, Farima Dalaei, Manraj N. Kaur, Lucas Gallo, Maarten Hoogbergen, Lotte Poulsen, Andrea L. Pusic, Stefan J. Cano   +9 more
wiley   +1 more source

A Review of Lifestyle Interventions Provided as an Adjunct to Obesity Management Medications

Obesity Science &Practice, Volume 12, Issue 4, August 2026.
ABSTRACT Objective This review synthesized the components of lifestyle interventions that have been provided in Phase 3 trials of obesity management medications (OMMs). Methods PubMed, CINAHL, and EMBASE were searched for Phase 3 clinical trials published from inception to February 2026 that tested FDA‐approved OMMs.
Ariana M. Chao, Ransford Asante, Maame Efua Sersah, Umar Anwar Jahangir, Alexandra Peary, Daniel Kudaya   +5 more
wiley   +1 more source

Clinical and economic considerations of antiobesity treatment: a review of orlistat

ClinicoEconomics and Outcomes Research, 2010
Armineh ZohrabianDivision of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USAAbstract: The objective of this study was to review the current knowledge about the use of orlistat from clinical and economic ...
Armineh Zohrabian
doaj  

Orlistat for the treatment of antipsychotic-induced weight gain: an eight-week multicenter, randomized, placebo-controlled, double-blind trial

Lipids in Health and Disease
Background Weight gain and metabolic disorders are commonly induced by antipsychotics. Orlistat is a lipase inhibitor used for weight control. The effect of orlistat on weight gain and metabolic disturbances in people (especially women) treated with ...
Peng Xie, Tiannan Shao, Yujun Long, Weiwei Xie, Yangjun Liu, Ye Yang, Yuyan Huang, Renrong Wu, Qijian Deng, Hui Tang   +9 more
doaj   +1 more source