Results 41 to 50 of about 11,081 (214)

orlistat improves release of gut hormones increasing satiety in obese women

Ожирение и метаболизм, 2014
Orlistat, which reduces fat absorption by inhibiting intestinal lipase is a registered drug for obesity pharmacotherapy. Meta-analyzes indicate various positive metabolic effects of orlistat, including improvements in glucose and lipid metabolism ...
Teona Albertovna Shvangiradze
doaj   +1 more source

TMT-Based Proteomics Analysis of the Intervention Effect of Orlistat on Polycystic Ovary Syndrome Rats Induced by Letrozole Combined with a High-Fat Diet

, 2023
Polycystic ovary syndrome (PCOS) is a complex gynecological endocrine and metabolic disease. Orlistat as a lipase inhibitor may improve the pathological characteristics of PCOS and is the sole antiobesity agent available in various countries.
Wang, Enli, Chen, Wenbin, Chen, Chen, Zhang, Guimin, Yao, Jingchun, Yang, Jianmei, Xu, Baihui   +6 more
core   +1 more source

High sensitivity of Giardia duodenalis to tetrahydrolipstatin (orlistat) in vitro. [PDF]

PLoS ONE, 2013
Giardiasis, a gastrointestinal disease caused by Giardia duodenalis, is currently treated mainly with nitroimidazoles, primarily metronidazole (MTZ).
Juliane Hahn, Frank Seeber, Herbert Kolodziej, Ralf Ignatius, Michael Laue, Toni Aebischer, Christian Klotz   +6 more
doaj   +1 more source

Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients [PDF]

, 2010
To evaluate the effects of 1-year treatment with orlistat plus L-carnitine compared to orlistat alone on body weight, glycemic and lipid control, and inflammatory parameters in obese type 2 diabetic patients.
Cicero AF, I. Palumbo, FERRARI, ILARIA, Palumbo I, G. Derosa, Sabrina Randazzo, Arrigo F.G. Cicero, Angela D’Angelo, D'ANGELO, ANGELA, DEROSA, GIUSEPPE, Ilaria Palumbo, Ilaria Ferrari, CICERO, ARRIGO FRANCESCO GIUSEPPE, I. Ferrari, Pamela Maffioli, FOGARI, ELENA, P. Maffioli, Giuseppe Derosa, A. D'Angelo, MAFFIOLI, PAMELA, Randazzo S, E. Fogari, Elena Fogari, S. Randazzo   +23 more
core   +1 more source

Pragmatic study of orlistat 60 mg on abdominal obesity

, 2011
Background/Objectives: It is well established that combining a reduced calorie, low-fat diet with the lipase inhibitor orlistat results in significantly greater weight loss than placebo plus diet.
Frost, G.S., Matthews, P.M., S M Schwartz, Delafont, B., J D Beaver, E L Thomas, G Frost, Mishra, R.G., Gambarota, G., J D Bell, R Newbould, Thomas, E.L., P M Matthews, Bell, J.D., A W Rao, A Makwana, Berk, E.S., G Gambarota, Makwana, A., R G Mishra, B Delafont, E S Berk, Beaver, J.D., Schwartz, S.M., Newbould, R., Rao, A.W.   +25 more
core   +1 more source

The effect of orlistat on postprandial hypertriglyceridemia by oral fat loading test: a systematic review

Nutrición Hospitalaria
Orlistat induces weight loss by blocking hydrolysis of triglyceride in the intestine, and has thereby been associated with favorable changes in postprandial triglycerides (ppTGL).
Ana Rodríguez-Valle, María Ángeles Navarro Ferrando, Diana Boj Carceller, Mar González-Cantalejo, Jesús Fernando Escanero Marcén, Alejandro Sanz-Paris   +5 more
doaj   +1 more source

Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects

, 2003
The lipase inhibitor, orlistat, is used in the treatment of obesity and reduces fat absorption by about 30%. However, the mean weight loss induced by orlistat is less than expected for the degree of fat malabsorption.
O'Donovan, D., Wishart, J., Horowitz, M., Feinle-Bisset, C.   +3 more
core   +1 more source

Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients

, 2010
Our study wants to evaluate the effects of one year treatment with orlistat plus L-carnitine compared to orlistat alone on body weight, glycemic and lipid control, and insulin resistance state in type 2 diabetic patients.
FERRARI, ILARIA, Palumbo I, Sabrina Randazzo, Arrigo F.G. Cicero, Angela D’Angelo, D'ANGELO, ANGELA, Fogari E, DEROSA, GIUSEPPE, Ilaria Palumbo, Ilaria Ferrari, Cicero AFG, Pamela Maffioli, Giuseppe Derosa, MAFFIOLI, PAMELA, Randazzo S, Elena Fogari   +15 more
core   +2 more sources

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source