Catabolic Ornithine Carbamoyltransferase Activity Facilitates Growth of Staphylococcus aureus in Defined Medium Lacking Glucose and Arginine [PDF]
mBio, 2022 Previous studies have found that arginine biosynthesis in Staphylococcus aureus is repressed via carbon catabolite repression (CcpA), and proline is used as a precursor. Unexpectedly, however, robust growth of S.
Itidal Reslane +13 more
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Variant analysis and PGT-M of OTC gene in a Chinese family with ornithine carbamoyltransferase deficiency [PDF]
BMC Pregnancy and ChildbirthBackground Ornithine carbamoyltransferase deficiency (OTCD) is a kind of X-linked metabolic disease caused by a deficiency in ornithine transcarbamylase leading to urea cycle disorders.
Yao Zhou +5 more
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Late-Onset Ornithine Carbamoyltransferase Deficiency Accompanying Acute Pancreatitis and Hyperammonemia [PDF]
Case Reports in Medicine, 2013 Hyperammonemia related to urea cycle disorders is a rare cause of potentially fatal encephalopathy that is encountered in intensive care units (ICUs). Left undiagnosed, this condition may manifest irreversible neuronal damage.
Marcel Cerqueira Cesar Machado +2 more
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Clinical characteristics and molecular genetic analysis of ten cases of ornithine carbamoyltransferase deficiency in southeastern China [PDF]
Italian Journal of PediatricsBackground This study aimed to investigate the clinical and molecular genetic characteristics of ten children with ornithine carbamoyltransferase deficiency (OTCD) in southeastern China, as well as the correlation between the genotype and phenotype of ...
Gaopin Yuan +5 more
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Infarction or Metabolic Breakdown? Longitudinally Extensive Diffusion-Restricted Lesions from the Medulla Oblongata to the Lumbar Spinal Cord [PDF]
DiagnosticsA 78-year-old woman with a history of rheumatoid arthritis (treated with methotrexate) developed disturbed consciousness, emesis, and intestinal perforation. Initial labs revealed hyperammonemia (189 μg/dL) and hypertonic dehydration.
Yuka Nakaya +7 more
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Genetic constraints on protein loop evolution: out-of-frame stop codons limit Bacillus subtilis stationary-phase mutagenesis [PDF]
Frontiers in Molecular BiosciencesInsertion and deletion (indel) events in protein-coding DNA are associated with loss-of-function frameshift mutations. In silico studies have found that protein-coding regions are littered with out-of-frame stop codons (OSCs) which may restrict OSC ...
Carmen Vallin +2 more
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Frontiers in Plant Science, 2022 The carbamoyltransferase or aspartate carbamoyltransferase (ATCase)/ornithine carbamoyltransferase (OTCase) is an evolutionary conserved protein family, which contains two genes, ATCase and OTCase. The ATCase catalyzes the committed step in the synthesis
Yogeshwar V. Dhar +3 more
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Structure and Function of Ornithine Carbamoyltransferases [PDF]
European Journal of Biochemistry, 1977 The reaction catalyzed by ornithine carbamoyltransferase can participate in either the anabolism or the catabolism of arginine. The carbamoylation of ornithine, yielding citrulline, is involved in the biosynthetic sequences; the reverse reaction, the phosphorolysis of citrulline, is the second step of the arginine deiminase pathway.The ornithine ...
Legrain, Christiane +6 more
openaire +3 more sources
VALPROATE TOXICITY AND ORNITHINE CARBAMOYLTRANSFERASE DEFICIENCY
Lancet, The, 1986 J D S Kay
exaly +2 more sources
The role of non-native interactions in the folding of knotted proteins. [PDF]
PLoS Computational Biology, 2012 Stochastic simulations of coarse-grained protein models are used to investigate the propensity to form knots in early stages of protein folding. The study is carried out comparatively for two homologous carbamoyltransferases, a natively-knotted N ...
Tatjana Skrbić +2 more
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