Results 11 to 20 of about 3,470 (203)

Salt Stress Induces Imbalanced ADI Pathway Gene Expressions in Pediococcus acidilactici Drives Citrulline Accumulation as an Ethyl Carbamate Precursor in Soy Sauce

Food Bioengineering
Citrulline is the main precursor of a carcinogen compound ethyl carbamate (EC) in soy sauce. Accumulation of citrulline is mainly related to metabolism of arginine by Pediococcus acidilactici via the arginine deiminase (ADI) pathway during soy sauce ...
Xiaodie Chen, Jiran Zhang, Haoran Chen, Fang Fang   +3 more
doaj   +2 more sources

Extracellular Vesicles of Giardia duodenalis: Unravelling Their Virulence Factors and Potential to Induce Protection Against Experimental Giardiasis

Journal of Extracellular Biology
Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans‐kingdom exchange of proteins, nucleic acids, lipids, and metabolites.
Corral‐Ruiz Gerardo, Argüello‐García Raúl, Ortiz‐Lozano Dalia, Salazar‐Villatoro Lizbeth, Pech‐Santiago Edar Onam, Espinosa‐Cantellano Martha, Hernández‐Cueto Daniel, Silva‐Olivares D. Angélica, Betanzos Abigail, Ortega‐Pierres M. Guadalupe   +9 more
doaj   +2 more sources

Converting catabolic ornithine carbamoyltransferase to an anabolic enzyme.

Journal of Biological Chemistry, 1990
Pseudomonas aeruginosa has an anabolic and a catabolic ornithine carbamoyltransferase (OTCase). In vitro, these homologous enzymes catalyze the same reaction (ornithine + carbamoyl phosphate (CP) in equilibrium citrulline + Pi), yet in vivo they function unidirectionally owing to specific kinetic properties.
Baur, Heinz, Haas, Didier, Tricot, Catherine, Stalon, Victor   +3 more
openaire   +4 more sources

Human serum albumin regulates the ornithine carbamoyltransferase production of Streptococcus pyogenes CS24 in vitro

Journal of Advanced Pharmaceutical Technology & Research
The M12 protein is the main virulence factor of Streptococcus pyogenes as a mediator in the bacteria’s adhesion to numerous human proteins, including human serum albumin (HSA) and immunoglobulin.
Sri Agung Fitri Kusuma, Debbie Soefie Retnoningrum, Maria Immaculata Iwo, Reny Ellyasheva   +3 more
doaj   +2 more sources

Microbial Electrosynthesis Reshapes Energy Metabolism and Physiology in Clostridium ljungdahlii. [PDF]

Microb Biotechnol
Microbial electrosynthesis drives Clostridium ljungdahlii into a distinct stress‐associated physiological state, different from gas fermentation. Comparative multi‐omics and electron microscopy reveal physiological constraints that help explain the poor performance of MES.
Al Sbei S, Boto ST, Krüger T, Papenfort K, Westermann M, Jost A, Harnisch F, Brakhage AA, Rosenbaum MA.   +8 more
europepmc   +2 more sources

The loss of the urea cycle and ornithine metabolism in different insect orders: An omics approach. [PDF]

Insect Mol Biol
Among urea cycle enzymes, only the nitric oxide synthase gene is universally present across insect genomes. All Hemiptera species lack the enzymes needed to convert citrulline to arginine, and some also lack the pathway from arginine to ornithine. Putrescine and spermidine synthesis is conserved in all insects, but aphids lack the capability to produce
Martins JCS, Assunção Romão HA, Canettieri CK, Cercilian AC, Oliveira PRO, Ferreira C, Terra WR, de Oliveira Dias R.   +7 more
europepmc   +2 more sources

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole-Cell Factory Saccharomyces Cerevisae. [PDF]

Chembiochem
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Kwiatos N, Ossel S, Mutti FG.
europepmc   +2 more sources

Hyperammonemia of unknown cause in a young postpartum woman: a case report

Journal of Medical Case Reports, 2022
Background Hyperammonemia is a medical condition described as increased or elevated serum ammonia levels. High serum levels of ammonia can cause neurotoxicity. Sudden onset severe hyperammonemia may cause severe encephalopathy with brain damage.
Sadaf Hanif, Sher Muhammad Sethi
doaj   +1 more source

Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. [PDF]

J Biol Chem, 2009
Ornithine carbamoyltransferase (OTC) is a key enzyme in the urea cycle to detoxify ammonium produced from amino acid catabolism. OTC deficiency is an X-linked genetic disorder ranging from fatal in newborns to hyperammonemia and anorexia in adults ...
Yu W, Lin Y, Yao J, Huang W, Lei Q, Xiong Y, Zhao S, Guan KL.   +7 more
europepmc   +2 more sources

An in vitro explant model for studies of intestinal amino acid metabolism

Clinical Nutrition Experimental, 2020
Summary: Background & aims: The main role of the small intestine to absorb the bulk of dietary nutrients, including proteins and amino acids (AA). Enterocytes have long been considered a major player in amino acid homeostasis, especially the glutamine ...
Sandie Pestour, Morgane Couchet, Charlotte Breuillard, Christelle Corne, Nicolas Mathieu, Frédéric Lamarche, Eric Fontaine, Moïse Coëffier, Christophe Moinard   +8 more
doaj   +1 more source