Results 21 to 30 of about 1,132 (104)
ChemBioChem, Volume 27, Issue 9, 14 May 2026.This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos +2 more
wiley +1 more source
Identification of MscS as a Key L‐Glutamate Exporter in Bacillus methanolicus
Microbial Biotechnology, Volume 18, Issue 10, October 2025.l‐Glutamate export in the methylotrophic bacterium Bacillus methanolicus, driven by an MscS‐like mechanosensitive channel. Figure created with BioRender (https://BioRender.com/t99s28). ABSTRACT Small‐conductance mechanosensitive channels (MscS) are established l‐glutamate exporters in industrially relevant bacteria, yet their role in the methylotrophic
Luciana Fernandes Brito +5 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 7, Page 1238-1256, July 2025.ABSTRACT Protein sequence design is a highly challenging task, aimed at discovering new proteins that are more functional and producible under laboratory conditions than their natural counterparts. Deep learning‐based approaches developed to address this problem have achieved significant success.
Ayşenur Soytürk Patat +1 more
wiley +1 more source
Microbial Biotechnology, Volume 18, Issue 5, May 2025.In this study, we constructed a CR biosynthesis pathway in E. coli by introducing exogenous AGAT and GAMT. We integrated the reconstitution methionine cycle with a polyphosphate kinase‐based ATP regeneration system, achieving a CR titre of 5.27 g/L with a productivity of 0.22 g/L/h.
Yuhua Sheng +8 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 1, January 2025.Camellia seed oil is rich in bioactive compounds, which could promote the in vitro proliferation of Akkermansia muciniphila by reducing the oxidation–reduction potential of the media and activating the metabolism pathways involving energy and nucleic acid metabolism, protein synthesis, and environmental adaptation, thereby facilitating the nutrient ...
Xi Chen +3 more
wiley +1 more source
Aquaculture Research, Volume 2025, Issue 1, 2025.This systematic literature review and meta‐analysis synthesizes empirical findings regarding the application of vaccines against Streptococcus infections in tilapia culture. Beyond systematically assessing advances and future directions in anti‐Streptococcus vaccination, we examined vaccine effects on prechallenge immunomodulation and postchallenge ...
Abdulwakil Olawale Saba +6 more
wiley +1 more source
Quo vadis ureagenesis disorders? A journey from 90 years ago into the future
Journal of Inherited Metabolic Disease, Volume 47, Issue 6, Page 1120-1128, November 2024.Abstract The pathway of ammonia disposal in the mammalian organism has been described in 1932 as a metabolic cycle present in the liver in different compartments. In 1958, the first human disorder affecting this pathway was described as a genetic condition leading to cognitive impairment and constant abnormalities of amino acid metabolism.
Johannes Häberle +2 more
wiley +1 more source
Comparative analysis of gene and disease selection in genomic newborn screening studies
Journal of Inherited Metabolic Disease, Volume 47, Issue 5, Page 945-970, September 2024.Abstract Genomic newborn screening (gNBS) is on the horizon given the decreasing costs of sequencing and the advanced understanding of the impact of genetic variants on health and diseases. Key to ongoing gNBS pilot studies is the selection of target diseases and associated genes to be included.
Isabel R. Betzler +8 more
wiley +1 more source
An essential protease, FtsH, influences daptomycin resistance acquisition in Enterococcus faecalis
Molecular Microbiology, Volume 121, Issue 5, Page 1021-1038, May 2024.FtsH, a conserved protease, influences daptomycin resistance evolution rates in Enterococcus faecalis by indirectly affecting the availability of the chaperone repressor HrcA. FtsH is also essential in the wild‐type genetic background where its loss of function results in altered metabolism in terms of decreased extracellular acidification and ability ...
Zeus Jaren Nair +10 more
wiley +1 more source
Characterizing arginine, ornithine, and putrescine pathways in enteric pathobionts
MicrobiologyOpen, Volume 13, Issue 2, April 2024.The amino acid L‐arginine is converted by bacteria into a variety of downstream metabolites, including citrulline, agmatine, ornithine, putrescine, and gamma‐aminobutyric acid (GABA). Our study shows that both Gram‐negative bacteria (Escherichia coli, Klebsiella pneumoniae, Klebsiella aerogenes, Pseudomonas fluorescens, and Acinetobacter baumannii) and
Ian M. Lillie +5 more
wiley +1 more source