Results 71 to 80 of about 62,149 (264)

HPV-Driven Head and Neck Cancer: The European Perspective

Viruses
Head and neck squamous-cell carcinoma (HNSCC) has long been associated with tobacco and alcohol use. In the last two decades, however, human papillomavirus (HPV) infection has emerged as an important driver of these cancers, particularly in the ...
Wojciech Golusiński, Ewelina Golusińska-Kardach, Piotr Machczyński, Mateusz Szewczyk   +3 more
doaj   +1 more source

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Compliant hydrogel cuff coating with real‐time pressure monitoring and antibiofilm capabilities for ventilator‐associated pneumonia prophylaxis

BMEMat, EarlyView.
A soft‐compliant hydrogel cuff coating combines real‐time pressure monitoring with intrinsic antibacterial activity for prophylaxis of ventilator‐associated pneumonia. A flexible pressure‐sensing patch is embedded in the coating to enable wireless dynamic monitoring of endotracheal cuff pressure through Bluetooth.
Jin Chai, Yifu Tan, Jiaheng Liang, Shen Liu, Jiabin Zhao, Shanbo Ma, Chunxin Liu, Minghua Du, Mark Selvan, Xiaopeng Shi, Liqiang Song, Peng Li   +11 more
wiley   +1 more source

Anatomy of the Soft Palate and Its Role in Upper Airway Function: A Narrative Review

Clinical Anatomy, EarlyView.
ABSTRACT The soft palate is a complex anatomical structure, located at the posterior aspect of the oral and nasal cavities, able to dynamically create valve closure of the nasal and the oral cavities. Its precise movement is critical for speech, swallowing, and respiration. Despite its functional importance, detailed characterization of its constituent
James C. D. Miller, Nikki Mills, Ho‐Fung Chan, Alys R. Clark, S. Ali Mirjalili   +4 more
wiley   +1 more source

Lymphomatoid Granulomatosis of the Oropharynx

Ear, Nose & Throat Journal, 1980
A case of lymphomatoid granulomatosis presenting as midline granuloma has been reported because of the rarity and rapidly fatal course of the disease. The lesion primarily occupied the oropharynx, affecting the posterior pharyngeal wall, uvula, and posterior third of the tongue and extending on to the larynx to invade arytenoid cartilage, true and ...
S, Gupta, O P, Gupta
openaire   +2 more sources

A Survival Epidemiology Framework for Oral and Oropharyngeal Cancer

Cancer Nexus, EarlyView.
ABSTRACT Oral and oropharyngeal cancer remains a major global public health burden, but the literature addressing this disease is still organized predominantly around who develops it rather than around what determines life after diagnosis. That imbalance is consequential because diagnosis initiates a new scientific problem.
Raphael E. Cuomo
wiley   +1 more source

MultNAT HPV16/18 Assay: A Simple, Rapid, and Low‐Cost Polymerase Chain Reaction Method for the Detection of HPV16 and HPV18 Suitable for Point‐of‐Care Testing

Cancer Nexus, EarlyView.
ABSTRACT Aim Persistent high‐risk HPV infection can lead to the development of precancerous lesions, potentially progressing to invasive cancer. HPV status serves not only as a prognostic marker for squamous cell carcinoma (HNSCC) like oropharyngeal squamous cell carcinomas (OPSCC) but also significantly influences clinical management and treatment ...
Min Wang, Yueping Li, Qingting Bu, Peng Xiong, Suhang Li, Xiaoyan Li, Sisi Chen, Yanqiong Zhou, Siyu Li, Xiaojuan Jia   +9 more
wiley   +1 more source

Oral and Perioral Manifestations in Monkeypox Patients: A Systematic Review of Case Reports and Case Series

Jurnal Kedokteran Diponegoro
Background: Human monkeypox (MPX) is an infectious disease caused by the MPX virus. One of the manifestations caused by MPX in humans is lesions in the oral cavity and surrounding areas.
Fiki Muhammad Ridho, Mohammad Iqbal, Eko Puji Laksono, Rafael Sena Saraiva Leal   +3 more
doaj   +1 more source

Prognostic value of some tumor markers in unresectable stage IV oropharyngeal carcinoma patients treated with concomitant radiochemotherapy

Radiology and Oncology, 2015
Background. The aim of the study was to investigate how the expression of tumor markers p21, p27, p53, cyclin D1, EGFR, Ki-67, and CD31 influenced the outcome of advanced inoperable oropharyngeal carcinoma patients, treated with concomitant ...
Soba Erika, Budihna Marjan, Smid Lojze, Gale Nina, Lesnicar Hotimir, Zakotnik Branko, Strojan Primoz   +6 more
doaj   +1 more source