Results 91 to 100 of about 73,221 (300)

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Lymphomatoid Granulomatosis of the Oropharynx

Ear, Nose & Throat Journal, 1980
A case of lymphomatoid granulomatosis presenting as midline granuloma has been reported because of the rarity and rapidly fatal course of the disease. The lesion primarily occupied the oropharynx, affecting the posterior pharyngeal wall, uvula, and posterior third of the tongue and extending on to the larynx to invade arytenoid cartilage, true and ...
S, Gupta, O P, Gupta
openaire   +2 more sources

Imaging of the oral cavity and the oropharynx

, 2023
Imaging of the oral cavity and the oropharynx is essential for the diagnosis of neoplastic and nonneoplastic disease, assessment of the nature and extent of the lesion, detection of lymphadenopathy, design of the proper treatment, and follow-up after ...
SEMİZ OYSU, ASLIHAN
core  

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

HPV-Driven Head and Neck Cancer: The European Perspective

Viruses
Head and neck squamous-cell carcinoma (HNSCC) has long been associated with tobacco and alcohol use. In the last two decades, however, human papillomavirus (HPV) infection has emerged as an important driver of these cancers, particularly in the ...
Wojciech Golusiński, Ewelina Golusińska-Kardach, Piotr Machczyński, Mateusz Szewczyk   +3 more
doaj   +1 more source

Difficult Airway Control in a Neonatal Patient with Oropharynx Mass

, 2016
Yıl: 2016Cilt: 5Sayı: supplement 1ISSN: 2147-0634Sayfa Aralığı: 155 - 157 Metin Dili: İngilizce Öz: Başlık (İngilizce): Öz (İngilizce): Tracheal intubation using direct laryngoscopy has become an essential part in the anesthesia management of the ...
Ucar, Muharrem, Erdogan, Mehmet Ali, Ozkan, Ahmet Selim, Firat, Cemal, Yucel, Aytac, Durmus, Mahmut   +5 more
core  

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Compliant hydrogel cuff coating with real‐time pressure monitoring and antibiofilm capabilities for ventilator‐associated pneumonia prophylaxis

BMEMat, EarlyView.
A soft‐compliant hydrogel cuff coating combines real‐time pressure monitoring with intrinsic antibacterial activity for prophylaxis of ventilator‐associated pneumonia. A flexible pressure‐sensing patch is embedded in the coating to enable wireless dynamic monitoring of endotracheal cuff pressure through Bluetooth.
Jin Chai, Yifu Tan, Jiaheng Liang, Shen Liu, Jiabin Zhao, Shanbo Ma, Chunxin Liu, Minghua Du, Mark Selvan, Xiaopeng Shi, Liqiang Song, Peng Li   +11 more
wiley   +1 more source

Prevalence of commensal Neisseria species in the human oropharynx

Genome dataset associated with a study on prevalence of commensal Neisseria species in the human ...
London School of Hygiene & Tropical Medicine
core   +2 more sources

Magnetic resonance thermometry for hyperthermia in the oropharynx region [PDF]

Magnetic resonance thermometry (MRT) can measure in-vivo 3D-temperature changes in real-time and noninvasively. However, for the oropharynx region and the entire head and neck, motion potentially introduces large artifacts.
Paulides, Margarethus M., Kroesen, Michiel, Feddersen, Theresa V., Feddersen, Theresa V.; id_orcid, Poot, Dirk H.J., Poot, Dirk H.J.; id_orcid, Dirk H.J Poot, Hernandez-Tamames, Juan A.; id_orcid, Michiel Kroesen, Theresa V. Feddersen, van Rhoon, Gerard C., Paulides, Margarethus M.; id_orcid, Gerard C. van Rhoon, Juan A. Hernandez-Tamames, Hernandez-Tamames, Juan A., Margarethus M. Paulides   +15 more
core   +1 more source