Results 71 to 80 of about 4,808 (171)

Multi‐omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis

The FEBS Journal, Volume 292, Issue 22, Page 6054-6074, November 2025.
Systemic sclerosis (SSc) is a rare autoimmune disease, and lung complications (ILD) are the main cause of death. This study compared SSc patients with and without lung disease to healthy volunteers. We found increased inflammation, specific proteins, and higher triglyceride levels linked to lung disease progression. These findings suggest triglycerides
Selena Bouffette, Perrine Soret, Alice Cole, Emmanuel Nony, Pierre Barbier Saint Hilaire, Grégory Leclerc, Lamine Alaoui, Audrey Aussy, Isabelle Wehrle, Aude Le Gall, Mark Coulon, Marc Pallardy, Voon Ong, Jeanne Allinne, Philippe Moingeon, David Abraham, Christopher P. Denton   +16 more
wiley   +1 more source

Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1598-1615, October 2025.
ABSTRACT Ethnic variabilities can affect the outcome of drug pharmacokinetics (PK) and drug–drug interactions (DDI). This work aimed to develop four North American (NA) sub‐populations: White, African American, Asian American, and Hispanic_Latino suitable for physiologically based pharmacokinetic (PBPK) modeling and simulations.
Udoamaka Ezuruike, Jean Dinh, Eman El‐Khateeb, Alex Blenkinsop, Oliver Hatley, Iain Gardner   +5 more
wiley   +1 more source

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, Volume 103, Issue 4, Page 540-566, October 2025.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

Orosomucoid on the surface and inside the leukocytes in myocardial infarction

Current Issues in Pharmacy and Medical Sciences, 2010
We investigated the concentration  and distribution of ORM in blood cells of 12 patients collected at the first day after the heart attack. We showed that the level of  ORM was increased 1.27 times in the serum in myocardial infarction.
Oleksandr Brazaluk, Anna Maslak, Ivan Mashejko, Olena Koval, Oleksandr Minchenko   +4 more
doaj  

Orosomucoid 2 (ORM2) in type 2 diabetes and coronary artery disease: a potential link between insulin resistance and vascular inflammation

Frontiers in Cardiovascular Medicine
Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are closely linked cardiometabolic disorders that share common inflammatory, metabolic, and vascular mechanisms.
Xia Sun, Xiang Tang, Guoyue Yuan
doaj   +1 more source

Dynamic changes of serum protein in rats with acute intoxication of Chinese cobra snake venom by proteomic analysis

Forensic Sciences Research, 2020
To elucidate the toxic mechanism of snake venom at the protein level, proteomics technology was applied to investigate the effect of venom on circulation in the mammalian body.
Hui Yan, Ping Xiang, Jingshuo Zhang, Liqi Xie, Min Shen   +4 more
doaj   +1 more source

A point-of-care assay for alpha-1-acid glycoprotein as a diagnostic tool for rapid, mobile-based determination of inflammation

Current Research in Biotechnology, 2019
Background: Inflammation is a key component of immune response to infections and pathogenesis of metabolic and cardiovascular diseases. Inflammatory biomarkers, including alpha-1-acid glycoprotein (AGP), are considered prognostic tools for predicting ...
Bryan M. Gannon, Marshall J. Glesby, Julia L. Finkelstein, Tony Raj, David Erickson, Saurabh Mehta   +5 more
doaj   +1 more source

Investigating the Association of Orosomucoid 1-like 3 (ORMDL3) Gene Polymorphism (rs12603332) with Susceptibility to Allergic Asthma in Iranian Northwestern Azeri Population

Iranian Journal of Allergy, Asthma and Immunology, 2018
Orosomucoid 1-like 3 (ORMDL3) gene, located on chromosome 17q21, is an asthma candidate gene that encodes ORMDL3. This molecule has been reported to play a role in airway remodeling and bronchial hyper-responsiveness.
Ilghar Zeinaly, Naghmeh Vossoughi, Daniel Elieh Ali Komi, Tohid Kazemi, Zohreh Babaloo, Alireza Razavi, Mohammad Sajay-Asbaghi, Mahnaz Sadeghi-Shabestari   +7 more
doaj   +1 more source

The acute phase reactant orosomucoid-2 directly promotes rheumatoid inflammation

Experimental and Molecular Medicine
Acute phase proteins involved in chronic inflammatory diseases have not been systematically analyzed. Here, global proteome profiling of serum and urine revealed that orosomucoid-2 (ORM2), an acute phase reactant, was differentially expressed in ...
Ki-Myo Kim, Kang-Gu Lee, Saseong Lee, Bong-Ki Hong, Heejae Yun, Yune-Jung Park, Seung-Ah Yoo, Wan-Uk Kim   +7 more
doaj   +1 more source

Structure of the Carbohydrate Moiety of Orosomucoid [PDF]

Nature, 1962
OROSOMUCOID isolated from serum has been the subject of many investigations in recent years1–4. Popenoe5 isolated an α1-glycoprotein from the urine of patients with the nephrotic syndrome and showed it to be immunochemically identical to serum orosomucoid.
openaire   +1 more source