Results 61 to 70 of about 4,808 (171)

Monitoring Urinary Orosomucoid in Acute Inflammation: Observations on Urinary Excretion of Orosomucoid, Albumin, α1-Microglobulin, and IgG [PDF]

Clinical Chemistry, 2005
AbstractBackground: Inflammation-associated proteinuria in acute, nonrenal disease is a common but poorly understood phenomenon. We performed an observational study of the urinary excretion of orosomucoid (α1-acid glycoprotein), albumin, α1-microglobulin (protein HC), and IgG to obtain quantitative and temporal data on these 4 proteins.Methods: Urine ...
Erik, Magid, Henrik, Guldager, Dan, Hesse, Merete Skovdal, Christiansen   +3 more
openaire   +2 more sources

Childhood Environmental Exposures and Adult Disease

Pediatric Pulmonology, Volume 61, Issue 4, April 2026.
ABSTRACT The association of early life adverse events with worse adult outcomes was first proposed by David Barker, the Developmental Origins of Health and Disease (DOHaD). Subsequently we have learned that adverse exposures are not merely important during pregnancy, but also exert transgenerational effects.
Andrew Bush
wiley   +1 more source

Plasma Proteomic Signatures of Pediatric Sepsis Reveal Persistent Inflammation and Phase‐Specific Biomarkers

FASEB BioAdvances, Volume 8, Issue 3, March 2026.
We enrolled a pediatric sepsis cohort at acute and recovery phases for plasma proteomics analysis. Abundantly expressed proteins in sepsis were identified and subjected to machine learning. In addition, the data was compared to adult sepsis and sterile inflammation.
Fahd Alhamdan, Yi‐Cheng Sin, Erik Malm, Hanna Van Pelt, Samuel Kim, LeeAnn Higgins, Yue Chen, Koichi Yuki   +7 more
wiley   +1 more source

Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes

EBioMedicine, 2017
The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully understood. Here, we report a role of Orm1 as an executer of HPC proliferation. Increases in serum
Xian-Yang Qin, Mitsuko Hara, Erik Arner, Yoshikuni Kawaguchi, Ikuyo Inoue, Hideki Tatsukawa, Yutaka Furutani, Keisuke Nagatsuma, Tomokazu Matsuura, Feifei Wei, Jun Kikuchi, Hideko Sone, Carsten Daub, Hideya Kawaji, Timo Lassmann, Masayoshi Itoh, Harukazu Suzuki, Piero Carninci, Yoshihide Hayashizaki, Norihiro Kokudo, Alistair R.R. Forrest, Soichi Kojima   +21 more
doaj   +1 more source

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, Volume 604, Issue 4, Page 1558-1574, 15 February 2026.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

Proteomic Evidence of Complement and Coagulation Pathway Dysregulation in Transfusion‐Dependent Thalassemia

Advances in Hematology, Volume 2026, Issue 1, 2026.
Transfusion‐dependent thalassemia (TDT) is characterized by chronic hemolysis, ineffective erythropoiesis, and iron overload, resulting in persistent oxidative stress and systemic inflammation. Patients with TDT are also at increased risk of thromboembolic complications, suggesting disturbance of hemostatic and immune‐related pathways.
Afshan Sumera, Ammu K. Radhakrishnan, Abdul Aziz Baba, Soon Keng Cheong, Kalyani Sen   +4 more
wiley   +1 more source

Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?

Therapeutics and Clinical Risk Management, 2019
Balázs Németh,1,2 Iván Péter,1 Imre Boncz,1 Anna Jagicza,1 István Kiss,2 Ágnes Csergő,2 Tamás Kőszegi,3,4 Péter Kustán,3,4 Iván G Horváth,5 Zénó ...
Németh B, Péter I, Boncz I, Jagicza A, Kiss I, Csergő Á, Kőszegi T, Kustán P, Horváth IG, Ajtay Z   +9 more
doaj  

Serum Sialic Acid as a Biomarker of Inflammation and Infection: Insights From Veterinary Medicine

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Serum sialic acid (SSA) levels, including total sialic acid (TSA), lipid‐bound sialic acid (LBSA), and protein‐bound sialic acid (PBSA), have been extensively studied as biomarkers of inflammation and infection across various species and diseases. In parasitemic sheep, elevated SSA levels likely reflect host–pathogen interactions and immune activation.
Tina Yaghoobpour, Milad Faraji, Saeed Nazifi, Antonio Ortega-Pacheco   +3 more
wiley   +1 more source

Differential Expression of Ormdl Genes in the Islets of Mice and Humans with Obesity

iScience, 2020
Summary: The orosomucoid-like (Ormdl) proteins play a critical role in sphingolipid homeostasis, inflammation, and ER stress, all of which are associated with obesity and βcell dysfunction. However, their roles in β cells and obesity remain unknown. Here,
Hugo Lee, Rachel J. Fenske, Tugce Akcan, Elliot Domask, Dawn B. Davis, Michelle E. Kimple, Feyza Engin   +6 more
doaj   +1 more source

Orosomucoid-1 Expression in Ameloblastoma Variants.

International journal of molecular and cellular medicine, 2016
Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus.
García Muñoz, Alejandro, Bologna-Molina, Ronell, Rodríguez, Mario A., Liceága-Reyes, Rodrigo, Farfán Morales, José Eduardo, Aranda-Romo, Saray, Molina-Frechero, Nelly, González González, Rogelio   +7 more
openaire   +3 more sources