Results 41 to 50 of about 4,733 (120)

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

Excretion of urinary orosomucoid 1 protein is elevated in patients with chronic heart failure. [PDF]

PLoS ONE, 2014
Easily screening markers for early detection of chronic heart failure (CHF) are lacking. We identified twenty differently expressed proteins including orosomucoid 1(ORM1) in urine between patients with CHF and normal controls by proteomic methods ...
Li-na Hou, Fei Li, Qing-chun Zeng, Liang Su, Ping-an Chen, Zhi-hao Xu, Din-ji Zhu, Chang-hua Liu, Ding-li Xu   +8 more
doaj   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Internalization of retinol-binding protein in parenchymal and stellate cells of rat liver.

Journal of Lipid Research, 1990
We have studied uptake of retinol-binding protein (RBP) by rat liver cells. First, we compared the in vivo uptake in different liver cells of 125I-labeled RBP with that of other well-known ligands.
H Senoo, E Stang, A Nilsson, GM Kindberg, T Berg, N Roos, KR Norum, R Blomhoff   +7 more
doaj   +1 more source

Childhood Environmental Exposures and Adult Disease

Pediatric Pulmonology, Volume 61, Issue 4, April 2026.
ABSTRACT The association of early life adverse events with worse adult outcomes was first proposed by David Barker, the Developmental Origins of Health and Disease (DOHaD). Subsequently we have learned that adverse exposures are not merely important during pregnancy, but also exert transgenerational effects.
Andrew Bush
wiley   +1 more source

Plasma Proteomic Signatures of Pediatric Sepsis Reveal Persistent Inflammation and Phase‐Specific Biomarkers

FASEB BioAdvances, Volume 8, Issue 3, March 2026.
We enrolled a pediatric sepsis cohort at acute and recovery phases for plasma proteomics analysis. Abundantly expressed proteins in sepsis were identified and subjected to machine learning. In addition, the data was compared to adult sepsis and sterile inflammation.
Fahd Alhamdan, Yi‐Cheng Sin, Erik Malm, Hanna Van Pelt, Samuel Kim, LeeAnn Higgins, Yue Chen, Koichi Yuki   +7 more
wiley   +1 more source

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, Volume 604, Issue 4, Page 1558-1574, 15 February 2026.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

Proteomic Evidence of Complement and Coagulation Pathway Dysregulation in Transfusion‐Dependent Thalassemia

Advances in Hematology, Volume 2026, Issue 1, 2026.
Transfusion‐dependent thalassemia (TDT) is characterized by chronic hemolysis, ineffective erythropoiesis, and iron overload, resulting in persistent oxidative stress and systemic inflammation. Patients with TDT are also at increased risk of thromboembolic complications, suggesting disturbance of hemostatic and immune‐related pathways.
Afshan Sumera, Ammu K. Radhakrishnan, Abdul Aziz Baba, Soon Keng Cheong, Kalyani Sen   +4 more
wiley   +1 more source

Serum Sialic Acid as a Biomarker of Inflammation and Infection: Insights From Veterinary Medicine

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Serum sialic acid (SSA) levels, including total sialic acid (TSA), lipid‐bound sialic acid (LBSA), and protein‐bound sialic acid (PBSA), have been extensively studied as biomarkers of inflammation and infection across various species and diseases. In parasitemic sheep, elevated SSA levels likely reflect host–pathogen interactions and immune activation.
Tina Yaghoobpour, Milad Faraji, Saeed Nazifi, Antonio Ortega-Pacheco   +3 more
wiley   +1 more source

Differential Expression of Ormdl Genes in the Islets of Mice and Humans with Obesity

iScience, 2020
Summary: The orosomucoid-like (Ormdl) proteins play a critical role in sphingolipid homeostasis, inflammation, and ER stress, all of which are associated with obesity and βcell dysfunction. However, their roles in β cells and obesity remain unknown. Here,
Hugo Lee, Rachel J. Fenske, Tugce Akcan, Elliot Domask, Dawn B. Davis, Michelle E. Kimple, Feyza Engin   +6 more
doaj   +1 more source