Results 31 to 40 of about 4,733 (120)

α-1 acid glycoprotein inhibits insulin responses by glucose oxidation, protein synthesis and protein breakdown in mouse C2C12 myotubes

Animal, 2019
Increased plasma α-1 acid glycoprotein (AGP) is correlated with reduced growth rates in neonatal swine. The specific physiological mechanisms contributing to this relationship are unknown.
T.G. Ramsay, L.A. Blomberg, T.H. Elsasser, T.J. Caperna   +3 more
doaj   +1 more source

Salivary orosomucoid 1 as a biomarker of hepatitis B associated hepatocellular carcinoma

Scientific Reports, 2022
Saliva is rich in proteins, DNA, RNA and microorganisms, and can be regarded as a biomarker library. In order to explore a noninvasive and simple means of early screening for liver cancer, proteomics was used to screen salivary markers of hepatitis B ...
Jiaoxia He, Zhongling Zheng, Tingting Liu, Yupei Ao, Yixuan Yang, Huaidong Hu   +5 more
doaj   +1 more source

Association of the serological status of rheumatoid arthritis patients with two circulating protein biomarkers: A useful tool for precision medicine strategies

Frontiers in Medicine, 2022
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence of systemic autoantibodies, with a great clinical and molecular heterogeneity.
Cristina Ruiz-Romero, Cristina Ruiz-Romero, Patricia Fernández-Puente, Lucía González, Anna Illiano, Anna Illiano, Lucía Lourido, Rocío Paz, Patricia Quaranta, Eva Perez-Pampín, Antonio González, Francisco J. Blanco, Francisco J. Blanco, Valentina Calamia   +13 more
doaj   +1 more source

Orosomucoid: a promising biomarker for the assessment of exercise-induced fatigue triggered by basic combat training

BMC Sports Science, Medicine and Rehabilitation, 2022
Background Orosomucoid (ORM) is a positive acute phase protein verified to be upregulated in various forms of exercise-induced fatigued (EIF) rodents. However, its association with EIF among human beings remained unknown.
Yi Ruan, Ke-fa Xiang, Hui-min Zhang, Zhen Qin, Yang Sun, Jing-jing Wan, Wei Gu, Xia Liu   +7 more
doaj   +1 more source

Spectroscopic and Theoretical Analysis of the Interaction between Plasma Proteins and Phthalimide Analogs with Potential Medical Application

Life, 2023
One of the groups of organic compounds with potential use in medicine and pharmacy is phthalimide derivatives. They are characterized by a wide range of properties such as antibacterial, antifungal, and anti-inflammatory.
Edward Krzyżak, Aleksandra Kotynia, Dominika Szkatuła, Aleksandra Marciniak   +3 more
doaj   +1 more source

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

BMC Pharmacology and Toxicology, 2018
Background Recent studies indicate that inflammation may also affect CYP3A4 activity. Associations of CYP3A4-mediated metabolism of quinine, with inflammatory biomarkers were investigated in patients undergoing maintenance hemodialysis (HD).
Hadi Molanaei, Abdul Rashid Qureshi, Olof Heimbürger, Bengt Lindholm, Ulf Diczfalusy, Björn Anderstam, Leif Bertilsson, Peter Stenvinkel   +7 more
doaj   +1 more source

ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function

Frontiers in Immunology, 2020
Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme for sphingolipid biosynthesis in cells.
Christopher R. Luthers, Teresa M. Dunn, Teresa M. Dunn, Andrew L. Snow   +3 more
doaj   +1 more source

Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway

Cell Reports, 2023
Summary: The therapeutic administration of recombinant proteins is utilized in a multitude of research studies for treating various diseases. In this study, we investigate the therapeutic potential of Orosomucoid 2 (Orm2), an acute phase protein ...
Li Li, Haoming Sun, Jionghao Chen, Cong Ding, Xiaojun Yang, Hua Han, Qingzhu Sun   +6 more
doaj   +1 more source

Retinal vascular caliber is associated with cardiovascular biomarkers of oxidative stress and inflammation: the POLA study.

PLoS ONE, 2013
PurposeRetinal vascular caliber has been linked with increased cardiovascular risk and is predictive of cardiovascular pathology, including stroke and coronary heart disease. Oxidative stress, as well as inflammatory mechanisms, plays a major role in the
Vincent Daien, Isabelle Carriere, Ryo Kawasaki, Jean-Paul Cristol, Max Villain, Pierre Fesler, Karen Ritchie, Cecile Delcourt   +7 more
doaj   +1 more source

Biosynthesis of long chain base in sphingolipids in animals, plants and fungi

Future Science OA, 2020
Long chain base (LCB) is a unique building block found in sphingolipids. The initial step of LCB biosynthesis stems from serine:palmitoyl-CoA transferase enzyme, producing 3-ketodihydrosphingosine with multiple regulatory proteins including small subunit
Ryuichi Mashima, Torayuki Okuyama, Mari Ohira   +2 more
doaj   +1 more source