Results 21 to 30 of about 4,808 (171)

Hepatokine ORM2 suppresses pathological ferritinophagy to prevent acute tissue injury [PDF]

Cell Death and Disease
Acute tissue injuries trigger rapid cellular damage, but cell-intrinsic protective programs attenuate pathology through regulatory axes. Here, we demonstrate that Orosomucoid 2 (ORM2), a hepatokine, is significantly upregulated during drug-induced acute ...
Hongyi Tang, Shu Wang, Fang Liu, Boqian Shen, Feng Jiang, Xinyuan Xiong, Nan Yang, Huiqin Zhu, Rulin Zhang, Dongge Xia, Cong Cong, Yan Lu, Jie Yang, Jun Wu, Bing Zhou, Xuxu Sun   +15 more
doaj   +2 more sources

Orosomucoid 1 interacts with S100A12 and activates ERK signalling to expedite the advancement of bladder cancer [PDF]

Cell Adhesion & Migration
The research endeavors to expound the role of ORM1 in bladder cancer (BCa) and the implied response mechanism. RT-qPCR and Western blotting examined ORM1 and S100A12 expression. Functional experiments assessed the cellular phenotypes.
Zhe Liu, Xiaofeng Pu
doaj   +2 more sources

A New Biomarker Tool for Risk Stratification in “de novo” Acute Heart Failure (OROME)

Frontiers in Physiology, 2022
Background: Inflammation is one of the mechanisms involved in heart failure (HF) pathophysiology. Thus, the acute phase reactant protein, orosomucoid, was associated with a worse post-discharge prognosis in de novo acute HF (AHF).
Rosa M. Agra-Bermejo, Rosa M. Agra-Bermejo, Rosa M. Agra-Bermejo, Carla Cacho-Antonio, Carla Cacho-Antonio, Eva Gonzalez-Babarro, Adriana Rozados-Luis, Marinela Couselo-Seijas, Inés Gómez-Otero, Inés Gómez-Otero, Inés Gómez-Otero, Alfonso Varela-Román, Alfonso Varela-Román, Alfonso Varela-Román, José N López-Canoa, José N López-Canoa, Isabel Gómez-Rodríguez, María Pata, Sonia Eiras, Sonia Eiras, Jose R. González-Juanatey, Jose R. González-Juanatey, Jose R. González-Juanatey   +22 more
doaj   +1 more source

Association Between Levels of the Acute Phase Proteins Alpha-1-Acid Glycoprotein and C-Reactive Protein and Serum Concentrations of Clozapine: A Study of 1106 Therapeutic Drug Monitoring Samples. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Several publications have reported elevated clozapine concentrations in patients experiencing infections or inflammatory reactions. Proposed mechanisms include increased levels of pro‐inflammatory cytokines that may inhibit clozapine metabolism and enhanced binding of clozapine to the acute phase protein alpha‐1‐acid glycoprotein (AGP).
Espnes KA, Spigset O, Bratt GE, Tilrem M, Hamnes S, Skogvoll E, Skråstad RB.   +6 more
europepmc   +2 more sources

Orosomucoid 1 Participates in Alveolar Hypercoagulation and Fibrinolytic Inhibition Involving NF-κB Signaling Pathway in LPS-Induced ARDS. [PDF]

FASEB J
ORM1 promotes LPS‐induced ARDS by activating NF‐κB in alveolar epithelial II cells, upregulating TF/PAI‐1 to cause hypercoagulation and fibrinolysis inhibition, leading to lung injury. ORM1 knockdown reverses these effects, indicating therapeutic potential.
Chen X, Liu Y, Mu S, Chen T, Yuan J, Xiao C, Dong Q, Li Q, Wang Y, Chen Q, Li S, Li W, Shen F.   +12 more
europepmc   +2 more sources

Serum Orosomucoid Is Associated with Serum Adiponectin, Adipose Tissue Insulin Resistance Index, and a Family History of Type 2 Diabetes in Young Normal Weight Japanese Women

Journal of Diabetes Research, 2022
Introduction. Adipose tissue (AT) expandability may be facilitated by adiponectin and suppressed by orosomucoid, and reduced AT expandability may be associated with first-degree relatives of type 2 diabetes.
Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Tomofumi Takayoshi, Yushi Hirota, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo   +9 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Into the Labyrinth of the Lipocalin α1-Acid Glycoprotein

Frontiers in Physiology, 2021
α1-acid glycoprotein (AGP), also known as Orosomucoid (ORM), belongs to the Lipocalin protein family and it is well-known for being a positive acute-phase protein.
Mario Ruiz
doaj   +1 more source

Orosomucoid, a new biomarker in the association between obesity and periodontitis. [PDF]

PLoS ONE, 2013
Epidemiological data indicate an association between periodontitis and obesity. The biological mechanisms of this relationship remain unclear. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common ...
Hélène Rangé, Christine Poitou, Adrien Boillot, Cécile Ciangura, Sandrine Katsahian, Jean-Marc Lacorte, Sébastien Czernichow, Olivier Meilhac, Philippe Bouchard, Catherine Chaussain   +9 more
doaj   +1 more source

The thermal polymerization of orosomucoid [PDF]

Biochemical Journal, 1969
1. Orosomucoid was prepared from the urine of a nephrotic patient and polymerized by heating it in a range of salt concentrations at pH4·1. 2. Heating at low ionic strengths produced a ‘chain’ polymer of indefinite length but having the same width as the diameter of the monomer (5·0nm.).
S P, Spragg, H B, Halsall, T H, Flewett, G R, Barclay   +3 more
openaire   +2 more sources