Results 21 to 30 of about 4,733 (120)

Urinary Proteomics Identifying Novel Biomarkers for the Diagnosis of Adult-Onset Still’s Disease

Frontiers in Immunology, 2020
Adult-onset Still’s disease (AOSD) is a systemic, multigenic autoinflammatory disease, and the diagnosis of AOSD must rule out neoplasms, infections, and other autoimmune diseases. Development of a rapid and efficient but non-invasive diagnosis method is
Yue Sun, Fan Wang, Zhuochao Zhou, Jialin Teng, Yutong Su, Huihui Chi, Zhihong Wang, Qiongyi Hu, Jinchao Jia, Tingting Liu, Honglei Liu, Xiaobing Cheng, Hui Shi, Yun Tan, Chengde Yang, Junna Ye   +15 more
doaj   +1 more source

Non-HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients. [PDF]

Diabetes Metab Res Rev
ABSTRACT Aim The genetic loci, ERBB2/IKZF3/GSDMB/ORMDL3 on chromosome 17q, and ERBB3/IKZF4 on chromosome 12q represent confirmed non‐HLA risk factors for the development of autoimmunity and progression to type 1 diabetes (T1D). It is unknown whether both regions can interact to influence the progression of T1D.
Mertens IM, Keymeulen B, Gorus FK, Van De Casteele M, Belgian Diabetes Registry.   +4 more
europepmc   +2 more sources

ORM Promotes Skeletal Muscle Glycogen Accumulation via CCR5-Activated AMPK Pathway in Mice

Frontiers in Pharmacology, 2016
We found previously that acute phase protein orosomucoid reacts to fatigue and activates C-C chemokine receptor type 5 to increase muscle glycogen storage and enhance muscle endurance (Lei et al., 2016). To explore the underlying molecular mechanisms, we
Zhen Qin, Jing-Jing Wan, Yang Sun, Peng-Yuan Wang, Ding-Feng Su, Hong Lei, Xia Liu   +6 more
doaj   +1 more source

Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort

Environmental Health, 2022
Introduction Air pollution is associated with increased risk of cardiovascular disease, possibly through chronic systemic inflammation that promotes the progression of atherosclerosis and the risk of cardiovascular events. This study aimed to investigate
Mehjar Azzouz, Yiyi Xu, Lars Barregard, Björn Fagerberg, Bengt Zöller, Peter Molnár, Anna Oudin, Mårten Spanne, Gunnar Engström, Leo Stockfelt   +9 more
doaj   +1 more source

Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort. [PDF]

Angew Chem Int Ed Engl
Validating biomarkers of disease is necessary for clinical use. The Health Surveillance Panel (83 peptides from 57 proteins) was developed as a PRM assay and evaluated using the Stellar‐MS platform. The assay was validated with a large clinical cohort of inflammatory bowel disease patients alongside quality controls.
Fu Q, Remes PM, Lee J, Jacob C, Li D, Vegesna M, Raedschelders K, Haghani A, Mengesha E, Debbas P, Hoedt E, Joung S, Cheng S, Peterman S, Fert-Bober J, Melmed GY, McGovern DPB, Murray CI, Van Eyk JE.   +18 more
europepmc   +3 more sources

INFLUENCE OF ALPHA-1-ACID GLYCOPROTEIN UPON PRODUCTION OF CYTOKINES BY PERIPHERAL BLOOD MONONUCLEARS

Медицинская иммунология, 2014
. Alpha-1-acid glycoprotein (orosomucoid) is a multifunctional acute phase reactant belonging to the family of lipocalines from plasma alpha-2 globulin fraction.
М. V. Osikov, L. V. Krivohizhina, E. V. Makarov, V. Yu. Akhmatov   +3 more
doaj   +1 more source

Study of urinary markers of different podocytopathies by proteomic analysis

Терапевтический архив, 2023
Background. Focal segmental glomerulosclerosis (FSGS) is a primary podocytopathy characterized by primary podocyte detection and high proteinuria. The search for biomarkers and factors associated with the progression of this disease is an important task ...
Anatoliy A. Vinogradov, Natalia V. Chebotareva, Anna E. Bugrova, Alexander G. Brzhozovskiy, Tatiana N. Krasnova, Karina Z. Nasibullina, Alexey S. Kononikhin, Sergey V. Moiseev   +7 more
doaj   +1 more source

Higher circulating orosomucoid, an acute-phase protein, and reduced glucose-induced insulin secretion in middle-aged Japanese people with prediabetes

BMJ Open Diabetes Research & Care, 2020
Introduction Circulating orosomucoid, an acute-phase protein, predicted type 2 diabetes mellitus risk in several Western countries. Here, we assessed serum orosomucoid (ORM) in relation to prediabetes in the Japanese.Research design and methods ...
Kaori Kitaoka, Mika Takeuchi, Ayaka Tsuboi, Miki Kurata, Tsutomu Kazumi, Keisuke Fukuo, Megumu Yano, Bin Wu, Mari Honda, Satomi Minato-Inokawa   +9 more
doaj   +1 more source

Higher circulating adiponectin and lower orosomucoid were associated with postload glucose ≤70 mg/dL, a possible inverse marker for dysglycemia, in young Japanese women

BMJ Open Diabetes Research & Care, 2019
Objective To examine whether serum adiponectin and orosomucoid were associated with postload glucose ≤70 mg/dL during an oral glucose tolerance test (OGTT), termed as postload low glycemia, a possible inverse marker for dysglycemia.Research design and ...
Satomi Minato, Kaori Kitaoka, Mika Takeuchi, Ayaka Tsuboi, Miki Kurata, Tsutomu Kazumi, Keisuke Fukuo, Megumu Yano, Gen Yoshino, Bin Wu   +9 more
doaj   +1 more source

Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis

Biomedicines, 2023
Aging is a growing problem worldwide, and the prevalence and mortality of arterial and venous thromboembolism (VTE) are higher in the elderly than in the young population. To address this issue, various anticoagulants have been used. However, no evidence
Seung Hee Lee, Suyeon Cho, Jong Youl Lee, Jung Yeon Hong, Suji Kim, Myong-Ho Jeong, Won-Ho Kim   +6 more
doaj   +1 more source