Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis [PDF]
Advanced ScienceTemporomandibular joint osteoarthritis (TMJOA) is one of the most complex temporomandibular disorders. Cartilage matrix degradation results in the infiltration of nerves, blood vessels, and inflammatory cells, which disrupts chondrocyte function ...
Dahe Zhang +5 more
doaj +3 more sources
Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic kidney Disease [PDF]
BMC Nephrology, 2023 Background Diabetic kidney disease (DKD) is the most common microvascular complication of diabetes, which has been a major cause of end-stage renal failure.
Xue-hong Zhou +4 more
doaj +2 more sources
Targeting ORM1-CCR5 axis inhibits the aggressive phenotype of synovial fibroblasts and alleviates RA [PDF]
Open MedicineThe present study focused on exploring the role of orosomucoid 1 (ORM1) in rheumatoid arthritis (RA).
Liu Min +5 more
doaj +2 more sources
A Cost-Effective and Easy to Assemble 3D Human Microchannel Blood–Brain Barrier Model and Its Application in Tumor Cell Adhesion Under Flow [PDF]
CellsBy utilizing polydimethylsiloxane (PDMS), collagen hydrogel, and a cell line for human cerebral microvascular endothelial cells, we produced a 3D microchannel blood–brain barrier (BBB) model under physiological flow.
Yunfei Li, Bingmei M. Fu
doaj +2 more sources
Conventional and Novel Inflammatory Biomarkers in Chronic Heart Failure Patients with Atrial Fibrillation [PDF]
Medicina(1) Background and Objectives: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with increased morbidity and mortality both in the general population and heart failure patients.
Gregor Vercek +5 more
doaj +2 more sources
Identification and validation of a nomogram for psoriasis diagnosis: a novel biomarker combination with stable high expression in the early stage [PDF]
Frontiers in MedicineObjectivePsoriasis is a complex chronic inflammatory skin disease. While typical cases are often diagnosed based on clinical features, achieving objective assessment of disease activity and precise early-stage identification remains a clinical focus ...
Juanli Liu +3 more
doaj +2 more sources
Molecular Dynamics Modeling of Potential Osteoarthritic Biomarkers [PDF]
LifeOsteoarthritis (OA) is one of the most common forms of arthritis and is commonly characterized by the breakdown of the hyaline cartilage and synovial fluid in joints. The body naturally responds by releasing proteins with specific functions to combat the
Joshua Mallets +2 more
doaj +2 more sources
Heparan Sulfate Modulation Affects Breast Cancer Cell Adhesion and Transmigration across In Vitro Blood–Brain Barrier [PDF]
CellsThe disruption of endothelial heparan sulfate (HS) is an early event in tumor cell metastasis across vascular barriers, and the reinforcement of endothelial HS reduces tumor cell adhesion to endothelium.
Yunfei Li +5 more
doaj +2 more sources
Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT [PDF]
NanomaterialsInhalation of multi-walled carbon nanotubes (MWCNTs) poses potential health risks due to their structural similarity to asbestos and their ability to induce chronic lung inflammation, fibrosis, and lung cancer in animal models.
Laura Aliisa Saarimäki +8 more
doaj +2 more sources
Maternal and Postnatal Umbilical Cord Blood Alpha-1-Acid Glycoprotein and Protein-Bound Hexose Levels as Inflammatory Biomarkers in Preeclampsia: A Case-Control Study [PDF]
Iranian Journal of Medical SciencesBackground: Preeclampsia (PE) is a multisystem disorder of unknown cause, leading to maternal and fetal morbidity and mortality. This study aimed to measure the inflammatory biomarkers alpha1-acid glycoprotein (α1-AGP) and protein-bound hexose (PBH) in ...
Jian Hussein +2 more
doaj +2 more sources