Results 51 to 60 of about 4,808 (171)

ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function

Frontiers in Immunology, 2020
Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme for sphingolipid biosynthesis in cells.
Christopher R. Luthers, Teresa M. Dunn, Teresa M. Dunn, Andrew L. Snow   +3 more
doaj   +1 more source

Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial

MedComm, Volume 7, Issue 8, August 2026.
Radiotherapy‐induced xerostomia severely impairs quality of life. Integrated multiomics, organoids, murine models, and a randomized Phase II trial identified spermidine as a key radiation‐responsive metabolite. Oral spermidine preserved salivary gland function, maintained acinar cell integrity through Golgi‐mediated posttranslational modifications ...
Yu Min, Kun Gao, Yingtong Liu, Lei Dai, Xingchen Peng   +4 more
wiley   +1 more source

Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway

Cell Reports, 2023
Summary: The therapeutic administration of recombinant proteins is utilized in a multitude of research studies for treating various diseases. In this study, we investigate the therapeutic potential of Orosomucoid 2 (Orm2), an acute phase protein ...
Li Li, Haoming Sun, Jionghao Chen, Cong Ding, Xiaojun Yang, Hua Han, Qingzhu Sun   +6 more
doaj   +1 more source

A Combined Transcriptomics and Proteomics Approach to Identify Immune Signatures in ANCA‐Associated Glomerulonephritis

ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Objective Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis often leads to severe kidney damage. To better understand ANCA‐associated glomerulonephritis (AAGN) and identify potential new therapeutic targets, we performed comprehensive transcriptomic and compartmental proteomic analysis of kidney biopsies from 23 patients in the ...
Ivana Stojkic, John P. Shapiro, Arnon Arazi, Huijuan Song, Pearlly Yan, Estela Puchulu‐Campanella, Hubao Wang, William E. Smoyer, Lynn A. Fussner, Anjali Satoskar, Xin Wang, Samir V. Parikh, Stacy P. Ardoin, Dan Koboldt, Brad H. Rovin, Salem Almaani   +15 more
wiley   +1 more source

Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort

Angewandte Chemie, Volume 137, Issue 46, November 10, 2025.
Validating biomarkers of disease is necessary for clinical use. The Health Surveillance Panel (83 peptides from 57 proteins) was developed as a PRM assay and evaluated using the Stellar‐MS platform. The assay was validated with a large clinical cohort of inflammatory bowel disease patients alongside quality controls.
Qin Fu, Philip M. Remes, Jihyeon Lee, Cristina Jacob, Dalin Li, Manasa Vegesna, Koen Raedschelders, Ali Haghani, Emebet Mengesha, Philip Debbas, Esthelle Hoedt, Sandy Joung, Susan Cheng, Scott Peterman, Justyna Fert‐Bober, Gil Y. Melmed, Dermot P.B. McGovern, Christopher I. Murray, Jennifer E. Van Eyk   +18 more
wiley   +2 more sources

Internalization of retinol-binding protein in parenchymal and stellate cells of rat liver.

Journal of Lipid Research, 1990
We have studied uptake of retinol-binding protein (RBP) by rat liver cells. First, we compared the in vivo uptake in different liver cells of 125I-labeled RBP with that of other well-known ligands.
H Senoo, E Stang, A Nilsson, GM Kindberg, T Berg, N Roos, KR Norum, R Blomhoff   +7 more
doaj   +1 more source

Biosynthesis of long chain base in sphingolipids in animals, plants and fungi

Future Science OA, 2020
Long chain base (LCB) is a unique building block found in sphingolipids. The initial step of LCB biosynthesis stems from serine:palmitoyl-CoA transferase enzyme, producing 3-ketodihydrosphingosine with multiple regulatory proteins including small subunit
Ryuichi Mashima, Torayuki Okuyama, Mari Ohira   +2 more
doaj   +1 more source

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Excretion of urinary orosomucoid 1 protein is elevated in patients with chronic heart failure. [PDF]

PLoS ONE, 2014
Easily screening markers for early detection of chronic heart failure (CHF) are lacking. We identified twenty differently expressed proteins including orosomucoid 1(ORM1) in urine between patients with CHF and normal controls by proteomic methods ...
Li-na Hou, Fei Li, Qing-chun Zeng, Liang Su, Ping-an Chen, Zhi-hao Xu, Din-ji Zhu, Chang-hua Liu, Ding-li Xu   +8 more
doaj   +1 more source