Results 51 to 60 of about 4,733 (120)

Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?

Therapeutics and Clinical Risk Management, 2019
Balázs Németh,1,2 Iván Péter,1 Imre Boncz,1 Anna Jagicza,1 István Kiss,2 Ágnes Csergő,2 Tamás Kőszegi,3,4 Péter Kustán,3,4 Iván G Horváth,5 Zénó ...
Németh B, Péter I, Boncz I, Jagicza A, Kiss I, Csergő Á, Kőszegi T, Kustán P, Horváth IG, Ajtay Z   +9 more
doaj  

Multi‐omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis

The FEBS Journal, Volume 292, Issue 22, Page 6054-6074, November 2025.
Systemic sclerosis (SSc) is a rare autoimmune disease, and lung complications (ILD) are the main cause of death. This study compared SSc patients with and without lung disease to healthy volunteers. We found increased inflammation, specific proteins, and higher triglyceride levels linked to lung disease progression. These findings suggest triglycerides
Selena Bouffette, Perrine Soret, Alice Cole, Emmanuel Nony, Pierre Barbier Saint Hilaire, Grégory Leclerc, Lamine Alaoui, Audrey Aussy, Isabelle Wehrle, Aude Le Gall, Mark Coulon, Marc Pallardy, Voon Ong, Jeanne Allinne, Philippe Moingeon, David Abraham, Christopher P. Denton   +16 more
wiley   +1 more source

Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization

Scientific Reports, 2023
Approximately 25–30% of those affected by colorectal cancer (CRC), the most prevalent gastrointestinal malignancy, develop metastases. The survival rate of patients with liver metastasis of CRC (CRLM) remains low owing to its unpredictability and a lack ...
Lei Yue, Xiaozhang Xu, Shipeng Dai, Fan Xu, Wenhu Zhao, Jian Gu, Xinzheng Dai, Xiaofeng Qian   +7 more
doaj   +1 more source

Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1598-1615, October 2025.
ABSTRACT Ethnic variabilities can affect the outcome of drug pharmacokinetics (PK) and drug–drug interactions (DDI). This work aimed to develop four North American (NA) sub‐populations: White, African American, Asian American, and Hispanic_Latino suitable for physiologically based pharmacokinetic (PBPK) modeling and simulations.
Udoamaka Ezuruike, Jean Dinh, Eman El‐Khateeb, Alex Blenkinsop, Oliver Hatley, Iain Gardner   +5 more
wiley   +1 more source

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, Volume 103, Issue 4, Page 540-566, October 2025.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

Network Modeling of Biomarker Systems in Liver Steatosis and Fibrosis

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease causes hepatic fat accumulation (steatosis) and fibrosis, which can be measured with ultrasound elastography imaging. The dependencies of elastography‐derived hepatic steatosis and fibrosis measures with chronic inflammation, disease states, and physiological determinants of drug dosing ...
Amruta Gajanan Bhat, Murali Ramanathan
wiley   +1 more source

Higher Levels of Cardiovascular Biomarkers Following Hypertensive Compared to Normotensive Pregnancy

Pregnancy, Volume 1, Issue 5, September 2025.
Abstract Hypertensive disorder of pregnancy (HDP) is associated with an increased risk for later‐life cardiovascular disease (CVD). Whether the HDP pregnancy itself confers risk toward CVD later in life is suggested in several epidemiologic studies. Given this connection and that the HDP exposure itself may play a role, understanding whether markers ...
Austin M. Gabel, Lindsay Cheu, Mindy Pike, Kelsey L. Olerich, Alisa Kachikis, Stephen A. McCartney, Raj Shree   +6 more
wiley   +1 more source

Dynamic changes of serum protein in rats with acute intoxication of Chinese cobra snake venom by proteomic analysis

Forensic Sciences Research, 2020
To elucidate the toxic mechanism of snake venom at the protein level, proteomics technology was applied to investigate the effect of venom on circulation in the mammalian body.
Hui Yan, Ping Xiang, Jingshuo Zhang, Liqi Xie, Min Shen   +4 more
doaj   +1 more source

A point-of-care assay for alpha-1-acid glycoprotein as a diagnostic tool for rapid, mobile-based determination of inflammation

Current Research in Biotechnology, 2019
Background: Inflammation is a key component of immune response to infections and pathogenesis of metabolic and cardiovascular diseases. Inflammatory biomarkers, including alpha-1-acid glycoprotein (AGP), are considered prognostic tools for predicting ...
Bryan M. Gannon, Marshall J. Glesby, Julia L. Finkelstein, Tony Raj, David Erickson, Saurabh Mehta   +5 more
doaj   +1 more source

Investigating the Association of Orosomucoid 1-like 3 (ORMDL3) Gene Polymorphism (rs12603332) with Susceptibility to Allergic Asthma in Iranian Northwestern Azeri Population

Iranian Journal of Allergy, Asthma and Immunology, 2018
Orosomucoid 1-like 3 (ORMDL3) gene, located on chromosome 17q21, is an asthma candidate gene that encodes ORMDL3. This molecule has been reported to play a role in airway remodeling and bronchial hyper-responsiveness.
Ilghar Zeinaly, Naghmeh Vossoughi, Daniel Elieh Ali Komi, Tohid Kazemi, Zohreh Babaloo, Alireza Razavi, Mohammad Sajay-Asbaghi, Mahnaz Sadeghi-Shabestari   +7 more
doaj   +1 more source