Results 1 to 10 of about 1,806 (131)

Exponential Clonal Expansion of 5-Fluorocytosine–Resistant Candida tropicalis and New Insights into Underlying Molecular Mechanisms [PDF]

Emerging Infectious Diseases
In 2022, we initiated systematic 5-fluorocytosine susceptibility testing of Candida spp. isolates in Denmark; we observed a bimodal MIC distribution in C. tropicalis, with MICs >16 mg/L in half the isolates.
Nissrine Abou-Chakra, Karen Marie Thyssen Astvad, Jan Martinussen, Amalie Sofie Eilsø Munksgaard, Maiken Cavling Arendrup   +4 more
doaj   +2 more sources

In Silico Approach Triterpene Glycoside of H. atra Targeting Orotidine 5-Monophosphate Decarboxylase Protein (PfOMPDC) in P. falciparum Infection Mechanism. [PDF]

Biomed Res Int
This study accessed the potential antimalarial activity of triterpene glycoside of H. atra through targeting orotidine 5‐monophosphate decarboxylase protein (PfOMPDC) in P. falciparum by molecular docking. Nine triterpene glycosides from H. atra extract modeled the structure by the Corina web server and interacted with PfOMPDC protein by using Hex 8.0 ...
Utami PD, Setianingsih H, Sari DRT.
europepmc   +2 more sources

Exploring Aspartate Transcarbamoylase: A Promising Broad-Spectrum Target for Drug Development. [PDF]

Chembiochem
Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Chen S, Mondile Q, Du X, Wang C, Mukim M, Wrenger C, Dömling ASS, Tastan Bishop Ö, Groves MR.   +8 more
europepmc   +2 more sources

Analyzing the Reaction of Orotidine 5'-Phosphate Decarboxylase as a Way to Examine Some Key Catalytic Proposals. [PDF]

J Am Chem Soc, 2023
Asadi M, Warshel A.
europepmc   +2 more sources

Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions. [PDF]

Biochemistry, 2013
Goryanova B, Goldman LM, Amyes TL, Gerlt JA, Richard JP.   +4 more
europepmc   +3 more sources

A novel plasmid-based experimental system in Saccharomyces cerevisiae that enables the introduction of 10 different plasmids into cells. [PDF]

FEBS Open Bio
We developed the Saccharomyces cerevisiae strains termed Δ10 that exhibit auxotrophic behavior for 10 different nutrients and the plasmids with auxotrophic markers for use in Δ10 strains. Δ10 strains were able to maintain 10 types of plasmids by auxotrophic selection.
Dong G, Nakai T, Matsuzaki T.
europepmc   +2 more sources

Safety evaluation of the food enzyme phosphoinositide phospholipase C from the genetically modified Pseudomonas fluorescens strain PIC. [PDF]

EFSA J
Abstract The food enzyme phosphoinositide phospholipase C (1‐phosphatidyl‐1D‐myo‐inositol‐4,5‐bisphosphate inositoltrisphosphohydrolase EC 3.1.4.11.) is produced with the genetically modified Pseudomonas fluorescens strain PIC by DSM Food specialties B.V. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Lambré C, Barat Baviera JM, Bolognesi C, Cocconcelli PS, Crebelli R, Gott DM, Grob K, Lampi E, Mengelers M, Mortensen A, Rivière G, Steffensen IL, Tlustos C, Van Loveren H, Vernis L, Zorn H, Roos Y, Fernàndez-Fraguas C, Gomes A, Liu Y, Chesson A.   +22 more
europepmc   +2 more sources

Exploring Lead-Like Molecules of Traditional Chinese Medicine for Treatment Quest against Aliarcobacter butzleri: In Silico Toxicity Assessment, Dynamics Simulation, and Pharmacokinetic Profiling. [PDF]

Biomed Res Int
Background. Aliarcobacter butzleri is a Gram‐negative, curved or spiral‐shaped, microaerophilic bacterium and causes human infections, specifically diarrhea, fever, and sepsis. The research objective of this study was to employ computer‐aided drug design techniques to identify potential natural product inhibitors of a vital enzyme in this bacterium ...
Basharat Z, Ahmed I, Alnasser SM, Meshal A, Waheed Y.   +4 more
europepmc   +2 more sources

Indiscriminate binding by orotidine 5'-phosphate decarboxylase of uridine 5'-phosphate derivatives with bulky anionic c6 substituents. [PDF]

Biochemistry, 2007
Lewis CA, Wolfenden R.
europepmc   +3 more sources

Development and application of a fast and efficient CRISPR-based genetic toolkit in Bacillus amyloliquefaciens LB1ba02

Microbial Cell Factories, 2022
Background Bacillus amyloliquefaciens is generally recognized as food safe (GRAS) microbial host and important enzyme-producing strain in the industry. B.amyloliquefaciens LB1ba02 is a production strain suitable for secreting mesophilic α-amylase in the ...
Qinglong Xin, Yudan Chen, Qianlin Chen, Bin Wang, Li Pan   +4 more
doaj   +1 more source