Results 81 to 90 of about 160,551 (221)

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Phytochemical Nanoparticles for the Treatment of Neurological Disorders

Phytochemical Analysis, EarlyView.
ABSTRACT Neurological disorders impose a significant burden on the healthcare systems. The latest published data by WHO indicated that stroke was the second leading cause of death globally in 2020, with Alzheimer's disease (AD) and other dementias in the seventh position.
Touraj Ehtezazi, Satyajit D. Sarker
wiley   +1 more source

Access and benefit sharing biological materials for machines: Artificial intelligence, machine learning and deep learning

PLANTS, PEOPLE, PLANET, EarlyView.
Future research and development of biological materials for foods, feeds, fibres, materials and medicines will increasingly rely on information and knowledge using Artificial Intelligence (AI) applications for detecting patterns to make useful decisions.
Charles Lawson, Elizabeth Englezos, Michelle Rourke   +2 more
wiley   +1 more source

Drivers of Pharmaceutical Compounding: Regional Experience Analysis Using Irkutsk Pharmacy Organisations as a Case Study

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. National pharmacy compounding is a priority for providing the population with medicinal products, particularly the medicinal products lacking in the Russian Federation.
G. N. Kovalskaya, N. V. Verlan, E. N. Mikhalevich   +2 more
doaj   +1 more source

Policy Effectiveness in Managing Drug Shortages: Evidence From South Korea (2015–2024)

World Medical &Health Policy, EarlyView.
ABSTRACT Drug shortages represent a growing policy challenge for healthcare systems worldwide. This study investigates actual drug shortage events in South Korea from 2015 to 2024, using a “Shortage Occurred vs. Shortage Non‐Occurred” framework to distinguish real‐world disruptions from administrative classifications.
Seung‐Rae Yu
wiley   +1 more source

Economic Impact of Severe Early‐Onset Foetal Growth Restriction: A Multicentre Prospective Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Foetal growth restriction (FGR) affects 10% of pregnancies, contributing to 30% of stillbirths. Current management of early‐onset FGR (< 32 + 0 weeks' gestation) delivers the foetus before stillbirth or irreversible organ damage. The resulting preterm births create additional risks independent of FGR.
George Bray, Kasia Maksym, Maurvi Dilipkumar, Rebecca N. Spencer, Yuval Ginsberg, Tal Weissbach, Donald M. Peebles, Neil Marlow, Angela Huertas‐Ceballos, Gina Buquis, Jade Okell, Kurt Hecher, Anke Diemert, Dominique Singer, Stefan R. Hansson, David Ley, Francesc Figueras, Eduard Gratacós, Fatima Crispi, Anna L. David, Rachael Hunter   +20 more
wiley   +1 more source

Triticale–lupin intercropping offers a viable option for low‐input systems in Mediterranean environments

Annals of Applied Biology, EarlyView.
Triticale and lupin are promising candidates for sustainable intercropping in low‐input, mixed crop–livestock farming systems in the Mediterranean basin, where they can be grown as rain‐fed crops during the autumn‐winter period. A field trial conducted in Sardinia demonstrated several key findings: the slower canopy development and shorter stature of ...
Rosella Motzo, Francesco Giunta
wiley   +1 more source

Langerhans Cell Modulation in Atopic Dermatitis Is TLR2/SOCS1‐Dependent and JAK Inhibitor‐Sensitive

Allergy, EarlyView.
Constitutive exposure to TLR2 ligands can modify Langerhans cell (LC) activation capacity and outcome, being similar to LC in atopic dermatitis skin. While maturation marker and migration are impaired, the cytokine profile switches and favors atopic dermatitis‐related IL‐1β and IL‐18.
Yuxuan Deng, Nicole Leib, Sylvia Schnautz, Said Benfadal, Johannes Oldenburg, Thomas Bieber, Nadine Herrmann   +6 more
wiley   +1 more source

Venture philanthropy in rare disease therapy

Rare
Purpose: Rare diseases affect ∼350 million people globally, yet 94 % of those affected lack effective treatments due to funding gaps and high R&D costs.
JA Levine
doaj  

Long term management of patients with cryopyrin-associated periodic syndromes (CAPS): focus on rilonacept (IL-1 Trap)

Biologics: Targets & Therapy, 2008
Leigh D Church1, Sinisa Savic2, Michael F McDermott21Department of Rheumatology, Division of Immunity, Infection and Inflammation, Institute for Biomedical Research, The University of Birmingham, Birmingham, UK; 2Section of Musculoskeletal Disease, Leeds
Leigh D Church, Sinisa Savic, Michael F McDermott   +2 more
doaj