Results 221 to 230 of about 101,906 (351)

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8⁺ T cells. [PDF]

Front Immunol
Cai Z, Kozai M, Mita H, Takeuchi H, Mizuno S, Matsuo K, Takada K.   +6 more
europepmc   +1 more source

Novel Therapeutic Potential of Retinoid-Related Orphan Receptor α in Cardiovascular Diseases. [PDF]

Int J Mol Sci, 2023
Chen Y, Zhang SP, Gong WW, Zheng YY, Shen JR, Liu X, Gu YH, Shi JH, Meng GL.   +8 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Targeting the nuclear orphan receptor NR4A1: a key target in lung cancer progression and therapeutic resistance. [PDF]

Front Oncol
Jin M, Wang Y, Song M, Guo W, Li S, Pu Z.   +5 more
europepmc   +1 more source

The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula. [PDF]

Sci Rep, 2022
Allain F, Carter M, Dumas S, Darcq E, Kieffer BL.   +4 more
europepmc   +1 more source

The Chemokine SDF-1/CXCL12 Binds to and Signals through the Orphan Receptor RDC1 in T Lymphocytes [PDF]

, 2005
Karl Balabanian, Bernard Lagane, Simona Infantino, Ken Y.C. Chow, Julie Harriague, Barbara Moepps, Fernando Arenzana‐Seisdedos, Marcus Thelen, Françoise Bachelerie   +8 more
openalex   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Retinoic-Acid-Related Orphan Receptor Alpha Is Involved in the Regulation of the Cytoskeleton of Hair Follicle Stem Cells. [PDF]

Biomolecules
Zhang Y, Zhao X, Li S, Bai S, Zhang W.
europepmc   +1 more source

The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder. [PDF]

Mol Psychiatry, 2022
Ben Hamida S, Sengupta SM, Clarke E, McNicholas M, Moroncini E, Darcq E, Ter-Stepanian M, Fortier MÈ, Grizenko N, Joober R, Kieffer BL.   +10 more
europepmc   +1 more source