Results 21 to 30 of about 101,906 (351)

Discovery of new G protein-coupled receptors for lipid mediators

Journal of Lipid Research, 2004
Successful sequencing of the human genome has opened a new era in the life sciences and has greatly accelerated biomedical research. Among various research endeavors benefiting from established genomic information, one of the most fruitful areas is the ...
Dong-Soon Im
doaj   +1 more source

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR) [PDF]

, 2000
Nuclear receptors constitute a large family of ligand-modulated transcription factors that mediate cellular responses to small lipophilic molecules, including steroids, retinoids, fatty acids, and exogenous ligands. Orphan nuclear receptors with no known
Handschin, C., Podvinec, M., Meyer, U. A.   +2 more
core   +1 more source

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 [PDF]

, 2017
Medium chain fatty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3′-diindolylmethane. 3,3′-Diindolylmethane and decanoic acid acted as strong positive allosteric modulators of the function of each other and
De Vos, Steve, Gosmini, Romain, Hudson, Brian D., Jenkins, Laura, Labéguère, Frédéric, Mahmud, Zobaer Al, Milligan, Graeme, Tikhonova, Irina G., Ulven, Trond   +8 more
core   +3 more sources

Orphan Receptors in Prostate Cancer

The Prostate, 2022
Background: The identification of new cellular receptors has been increasing rapidly. A receptor is called “orphan” if an endogenous ligand has not been identified yet. Methods: Here we review receptors that contribute to prostate cancer and are considered orphan or partially orphan.
openaire   +3 more sources

Orphan receptor GPR158 controls stress-induced depression

eLife, 2018
Stress can be a motivational force for decisive action and adapting to novel environment; whereas, exposure to chronic stress contributes to the development of depression and anxiety.
Laurie P Sutton, Cesare Orlandi, Chenghui Song, Won Chan Oh, Brian S Muntean, Keqiang Xie, Alice Filippini, Xiangyang Xie, Rachel Satterfield, Jazmine D W Yaeger, Kenneth J Renner, Samuel M Young Jr, Baoji Xu, Hyungbae Kwon, Kirill A Martemyanov   +14 more
doaj   +1 more source

IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis

Nature Communications, 2023
Glioblastoma stem-like cells (GSCs) contribute to therapeutic resistance and recurrence of glioblastomas. Here the authors show that Insulin-like Growth Factor-Binding Protein 5 (IGFBP5) is a ligand for Receptor tyrosine kinase-like Orphan Receptor 1 ...
Weiwei Lin, Rui Niu, Seong-Min Park, Yan Zou, Sung Soo Kim, Xue Xia, Songge Xing, Qingshan Yang, Xinhong Sun, Zheng Yuan, Shuchang Zhou, Dongya Zhang, Hyung Joon Kwon, Saewhan Park, Chan Il Kim, Harim Koo, Yang Liu, Haigang Wu, Meng Zheng, Heon Yoo, Bingyang Shi, Jong Bae Park, Jinlong Yin   +22 more
doaj   +1 more source

Orexin Receptor Type-1 Couples Exclusively to Pertussis Toxin-Insensitive G-Proteins, While Orexin Receptor Type-2 Couples to Both Pertussis Toxin-Sensitive and -Insensitive G-Proteins

Journal of Pharmacological Sciences, 2003
Signal transduction pathways of orexin receptors were examined using a nerve-like cell line transfected with orexin receptor type-1 (OX1R) and orexin receptor type-2 (OX2R).
Yun Zhu, Yoshihiro Miwa, Akihiro Yamanaka, Toshihiko Yada, Megumi Shibahara, Yoichiro Abe, Takeshi Sakurai, Katsutoshi Goto   +7 more
doaj   +1 more source

Insights into orphan nuclear receptors as prognostic markers and novel therapeutic targets for breast cancer

Frontiers in Endocrinology, 2015
The roles of orphan nuclear receptors in breast cancer development and progression are not well understood. In this review, we correlate orphan nuclear receptor expression in breast cancer tumour subtypes with patient outcomes and provide an overview of ...
Reidun eAesoy, Reidun eAesoy, Colin D Clyne, Colin D Clyne, Ashwini eChand, Ashwini eChand, Ashwini eChand   +6 more
doaj   +1 more source

Alternative activation

eLife, 2023
A detailed study of the orphan receptor Nurr1, a regulator implicated in neurodegenerative diseases, reveals a new way for ligands to control their transcriptional activity.
Kristen Young, Sean Fanning
doaj   +1 more source

In Silico Adoption of an Orphan Nuclear Receptor NR4A1. [PDF]

PLoS ONE, 2015
A 4.1 μs molecular dynamics simulation of the NR4A1 (hNur77) apo-protein has been undertaken and a previously undetected druggable pocket has become apparent that is located remotely from the 'traditional' nuclear receptor ligand-binding site.
Harald Lanig, Felix Reisen, David Whitley, Gisbert Schneider, Lee Banting, Timothy Clark   +5 more
doaj   +1 more source