Results 301 to 310 of about 101,906 (351)

The mammalian orphan nuclear receptors: orphans as cellular guardians

Journal of Receptors and Signal Transduction, 2010
In classical endocrinology, receptors are molecules that bind a hormone or a ligand to transduce signal within a target cell. Later, however, many intracellular receptors have been discovered in mammals, which have not been shown to bind endogenous ligands and are now are referred as "orphan receptors." The orphan receptors share high degree of ...
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Orphan nuclear receptors adopted by crystallography

Current Opinion in Structural Biology, 2005
Of the large nuclear hormone receptor superfamily of proteins, orphan nuclear receptors have remained a mystery owing to their lack of identified ligands and their constitutive nature. Now, structures of several ligand-binding domains of orphan receptors have provided some surprising insights that were not anticipated from molecular studies. Therefore,
Holly A, Ingraham, Matthew R, Redinbo
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Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors

2017
Of the druggable group of G protein-coupled receptors in the human genome, a number remain which have yet to be paired with an endogenous ligand-orphan GPCRs. Among these 100 or so entities, 3 have been linked to the cannabinoid system. GPR18, GPR55, and GPR119 exhibit limited sequence homology with the established CB1 and CB2 cannabinoid receptors ...
Irving, Andrew, Abdulrazzaq, Ghayth, Chan, Sue L. F., Penman, June, Harvey, Jenni, Alexander, Stephen P. H.   +5 more
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Gene Silencing by Nuclear Orphan Receptors

2004
Nuclear orphan receptors represent a large and diverse subgroup in the nuclear receptor superfamily. Although putative ligands for these orphan members remain to be identified, some of these receptors possess intrinsic activating, inhibitory, or dual regulatory functions in development, differentiation, homeostasis, and reproduction.
Ying, Zhang, Maria L, Dufau
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Orphan nuclear receptors

The Journal of Steroid Biochemistry and Molecular Biology, 2012
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Seeking Ligands for Lonely Orphan Receptors

Science, 1999
Ligands for about half of the nuclear receptor superfamily, many members of which are involved in crucial metabolic pathways, have been identified so far. Those receptors, for which the ligands are not known, are called orphan nuclear receptors. Finding the ligands for these receptors is a big challenge for pharmaceutical companies. In his Perspective,
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Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul Parikh
exaly  

Chemical Genomics of Orphan Nuclear Receptors

2003
The steroid hormone, thyroid hormone, retinoic acid, and vitamin D receptors are members of a family of ligand-activated transcription factors (Mangelsdorf et al. 1995). These nuclear hormone receptors contain two signature domains, a central double zinc finger DNA-binding domain (DBD) and a C-terminal ligand-binding domain (LBD) (Fig. 1).
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Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Victoria Metaxa, Elie Azoulay   +2 more
exaly