Results 31 to 40 of about 12,462 (264)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Hope Groups: a protocol for a cluster randomized controlled trial of psychosocial, mental health, and parenting support groups for Ukrainian caregivers during war and conflict

Trials
Background In 2021, more than two-thirds of the world’s children lived in a conflict-affected country. In 2022, 13 million Ukrainians were forced to flee their homes after Russia’s full-scale invasion.
Sydney Tucker, Nicole Baldonado, Olha Ruina, Oliver Ratmann, Seth Flaxman, Lyudmyla Bryn, Jamie Lachman, Evgenia Taradaika, G. J. Melendez-Torres, Inge Vallance, Philip Goldman, Lucie Cluver, Susan Hillis   +12 more
doaj   +1 more source

Modern Foreign Approaches to Open Adoption

Современная зарубежная психология
Context and relevance. The article presents a review of foreign literature on open and closed adoption, presents the results of studies that have not previously been translated into Russian, which explore various aspects of an adopted child's ...
Y.F. Chinareva
doaj   +1 more source

Nutritional status and dietary diversity of orphan and non – orphan children under five years: a comparative study in the Brong Ahafo region of Ghana

BMC Nutrition, 2018
Background Undernutrition in children under 5 years is a major risk factor to child deaths and is related to impaired cognitive development and lower school performance.
Zakari Ali, Nurudeen Abu, Isaac Aning Ankamah, Esther Abena Gyinde, Alimatu Sadia Seidu, Abdul-Razak Abizari   +5 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Orphan drugs

Medicinski pregled, 2013
Introduction. Drugs used for treatment of rare diseases are known worldwide under the term of orphan drugs because pharmaceutical companies have not been interested in ?adopting? them, that is in investing in research, developing and producing these drugs.
Svetlana Golocorbin-Kon, Aleksandra Vojinovic, Mladena Lalic-Popovic, Nebojsa Pavlovic, Momir Mikov   +4 more
openaire   +3 more sources

Orphans in Mediterranean antiquity and early Christianity

Acta Theologica, 2016
This article provides an overview of the problem of orphans in the ancient Mediterranean world and identifies ways in which various societies acknowledged orphans’ plight and sought to address it.
J. T. Fitzgerald
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Family Composition and Stability for Orphans: A Longitudinal Study of Well-Being in 5 Low- and Middle-Income Countries

International Journal of Public Health, 2021
Objectives: Many orphaned children in low- and middle-income countries live with family. Yet, their household composition and its stability are not well-characterized, nor is impact of stability on longer-term outcomes.Methods: We used the longitudinal ...
Christine L. Gray, Christine L. Gray, Kathryn Whetten, Kathryn Whetten, Julie L. Daniels, Michael G. Hudgens, Audrey E. Pettifor, Amy M. Hobbie, Nathan M. Thielman, Nathan M. Thielman, Misganaw E. Dubie, Dafrosa Itemba, Ira Madan, Vanroth Vann, Augustine I. Wasonga, Rachel Manongi, Jan Ostermann, Jan Ostermann, Rachel A. Whetten, Brian W. Pence   +19 more
doaj   +1 more source