Results 41 to 50 of about 12,462 (264)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

ORPHANED PROTOSTARS [PDF]

The Astrophysical Journal, 2010
We explore the origin of a population of distant companions (~1000 - 5000 AU) to Class I protostellar sources recently found by Connelley and co-workers, who noted that the companion fraction diminished as the sources evolved. Here we present N-body simulations of unstable triple systems embedded in dense cloud cores.
Reipurth, Bo, Mikkola, Seppo, Connelley, Michael, Valtonen, Mauri   +3 more
openaire   +2 more sources

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Determinants of viral load suppression among orphaned and vulnerable children living with HIV on ART in Tanzania

Frontiers in Public Health, 2023
IntroductionIn Tanzania, only 66% children 0–14 years living with HIV know their HIV status, 66% are on treatment while 47% of children on ART are virally suppressed.
Amal Ally, Amon Exavery, John Charles, Levina Kikoyo, Remmy Mseya, Asheri Barankena, Rose Fovo, Akwila Temu   +7 more
doaj   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Exploring the Burden on Patients Living With and Receiving Treatment for Immune Thrombocytopenia (ITP): Patient and Physician Perceptions From the ITP World Impact Survey (I‐WISh) 2.0

American Journal of Hematology, EarlyView.
ABSTRACT Limited data exist on how patients and physicians perceive immune thrombocytopenia (ITP) symptoms and treatment‐related burden. I‐WISh (ITP World Impact Survey) 2.0 surveyed 1018 patients and 431 physicians in 15 countries to characterize the impact of ITP and its treatments on patients.
Nichola Cooper, James Bussel, Waleed Ghanima, Drew Provan, Yoshiaki Tomiyama, Ming Hou, Donald M. Arnold, Cristina Santoro, Francesco Zaja, Barbara Lovrencic, Mervyn Morgan, Michal Winograd, Jennifer DiRaimo, Danielle Boyle, Olivera Rajkovic‐Hooley, Meritxell Vendranas, Susan Frade, Caroline Kruse   +17 more
wiley   +1 more source

Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia

Journal of Virus Eradication, 2016
An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 ...
B.u.i.V.u. Huy, S.i.r.i.n.y.a. Teeraananchai, L.e.N.g.o.c. Oanh, J.o.h.n. Tucker, N.i.a. Kurniati, R.a.w.i.w.a.n. Hansudewechakul, K.h.a.n.h.H.u.u. Truong, V.o.h.i.t.h. Khol, L.a.m. Van Nguyen, V.i.e.t. Chau Do, P.a.g.a.k.r.o.n.g. Lumbiganon, N.a.n.t.a.k.a. Kongstan, T.o.r.s.a.k. Bunupuradah, T.a.v.i.t.i.y.a. Sudjaritruk, N.a.g.a.l.i.n.g.e.s.w.a.r.a.n. Kumarasamy, N.i.k.K.h.a.i.r.u.l.d.d.i.n.N.i.k. Yusoff, K.a.m.a.r.u.l.A.z.a.h.a.r. Mohd Razali, D.e.w.i.K.u.m.a.r.a. Wati, M.o.y.S.i.e.w. Fong, R.e.v.a.t.h.y. Nallusamy, A.z.a.r. Kariminia, A.n.n.e.t.t.e.H. Sohn   +21 more
doaj   +1 more source

Symptoms of Depression, Anxiety and Their Co-Occurrence among Orphaned Children in Sekhukhune District, Limpopo Province

Children, 2023
Although both short- and long-term psychological challenges, specifically depression and anxiety, have been reported among orphans, there is a dearth of studies that quantify these disorders in rural settings.
Kebogile Elizabeth Mokwena, Success Magabe, Busisiwe Ntuli   +2 more
doaj   +1 more source

Descriptive Epidemiology From the Myhre Syndrome Foundation Registry: The Value of Self‐Reported Data

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is an ultrarare genetic disease characterized by short stature, distinct craniofacial features, cardiovascular and respiratory fibrosis and stenosis, neurodevelopmental delays, autism, intellectual disability, and hearing loss. The natural history of Myhre syndrome is still not fully understood due to a small patient population ...
Mary K. Young, Armelle Pindon, Maggie R. Brand, Kate Wears, Katherine H. Young, Alyssa Mendel, Michael J. Lyons   +6 more
wiley   +1 more source

Physical activity and quality of life in adolescents and orphans

Exercise and Quality of Life, 2020
The aim of this study was to determine the relationship between physical activity and the quality of life in secondary school pupils and in orphans. The second aim was to determine differences in physical activity habits among groups.
Lucija Maglica, Hrvoje Karninčić, Ana Penjak, Gordan Drašinac   +3 more
doaj   +1 more source