Results 51 to 60 of about 29,818 (295)

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Targeting B‐Cell‐Activating Factor and Its Receptor in Immune Thrombocytopenia and Warm Autoimmune Hemolytic Anemia

American Journal of Hematology, EarlyView.
ABSTRACT Current treatments for immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (wAIHA), rare autoimmune diseases in which autoreactive B cells play a major role, can lead to high response rates; however, for many patients these responses are not durable or maintained after treatment discontinuation.
Matthieu Mahévas, Nichola Cooper, Vickie McDonald, Karina Yazdanbakhsh, Wilma Barcellini   +4 more
wiley   +1 more source

Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia

Journal of Virus Eradication, 2016
An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 ...
B.u.i.V.u. Huy, S.i.r.i.n.y.a. Teeraananchai, L.e.N.g.o.c. Oanh, J.o.h.n. Tucker, N.i.a. Kurniati, R.a.w.i.w.a.n. Hansudewechakul, K.h.a.n.h.H.u.u. Truong, V.o.h.i.t.h. Khol, L.a.m. Van Nguyen, V.i.e.t. Chau Do, P.a.g.a.k.r.o.n.g. Lumbiganon, N.a.n.t.a.k.a. Kongstan, T.o.r.s.a.k. Bunupuradah, T.a.v.i.t.i.y.a. Sudjaritruk, N.a.g.a.l.i.n.g.e.s.w.a.r.a.n. Kumarasamy, N.i.k.K.h.a.i.r.u.l.d.d.i.n.N.i.k. Yusoff, K.a.m.a.r.u.l.A.z.a.h.a.r. Mohd Razali, D.e.w.i.K.u.m.a.r.a. Wati, M.o.y.S.i.e.w. Fong, R.e.v.a.t.h.y. Nallusamy, A.z.a.r. Kariminia, A.n.n.e.t.t.e.H. Sohn   +21 more
doaj   +1 more source

Understanding Arthrogryposis Multiplex Congenita (AMC) Across the Lifespan: An Integrative Review of the Adult AMC Registry's Contributions With Lived Experience Partnerships

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT This reflective essay explores how collaborative work between researchers and adults living with Arthrogryposis Multiplex Congenita (AMC) has deepened and broadened our understanding of what it means to live with this rare condition. By intentionally integrating the lived experiences of individuals with AMC into research processes, the ...
Bonita J. Sawatzky, Megan K. MacGillivray, Tracey Schalk, William Bennett Mortenson   +3 more
wiley   +1 more source

Caregiver Reports on the Needs and Experiences of Children Impacted by Parental Incarceration: Results From an Australian Survey

Australian Journal of Social Issues, EarlyView.
ABSTRACT Children experiencing parental imprisonment are known to be among the most overlooked in our community. They often experience multiple and compounding disadvantages, with long‐term consequences, but receive no specialised assistance. Knowledge about these children and their families is lacking in Australia and is required to inform policy ...
Catherine Flynn, Lana Battaglia, Lorana Bartels, Susan Dennison, Susy Harrigan, Lee Huggins, Sofia Grage‐Moore   +6 more
wiley   +1 more source

A formative evaluation of the James House programme for orphans and vulnerable children [PDF]

, 2014
Includes bibliographical references.The increasing burden of care and support of orphaned children or those made vulnerable by HIV/AIDS remains a critical and challenging issue particularly in the South African context.
Mutenheri, Hellen
core   +1 more source

Needs and Problems of Adolescent Orphans at Governmental Residential Institutions in Alexandria [PDF]

Alexandria Scientific Nursing Journal
Background: The orphanhood is a widespread phenomenon in both developed and developing countries. Adolescent orphans have a wide range of fundamental problems and unmet needs that affect their health and development.
Amina Mohamed, Yasmin Badawy Boghdady, Ahlam Mohamed, Nagat Abd Alghany, Eman Abd Elbary   +4 more
doaj   +1 more source

Physical activity and quality of life in adolescents and orphans

Exercise and Quality of Life, 2020
The aim of this study was to determine the relationship between physical activity and the quality of life in secondary school pupils and in orphans. The second aim was to determine differences in physical activity habits among groups.
Lucija Maglica, Hrvoje Karninčić, Ana Penjak, Gordan Drašinac   +3 more
doaj   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source