Results 51 to 60 of about 154,634 (351)

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia

Journal of Virus Eradication, 2016
An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 ...
B.u.i.V.u. Huy, S.i.r.i.n.y.a. Teeraananchai, L.e.N.g.o.c. Oanh, J.o.h.n. Tucker, N.i.a. Kurniati, R.a.w.i.w.a.n. Hansudewechakul, K.h.a.n.h.H.u.u. Truong, V.o.h.i.t.h. Khol, L.a.m. Van Nguyen, V.i.e.t. Chau Do, P.a.g.a.k.r.o.n.g. Lumbiganon, N.a.n.t.a.k.a. Kongstan, T.o.r.s.a.k. Bunupuradah, T.a.v.i.t.i.y.a. Sudjaritruk, N.a.g.a.l.i.n.g.e.s.w.a.r.a.n. Kumarasamy, N.i.k.K.h.a.i.r.u.l.d.d.i.n.N.i.k. Yusoff, K.a.m.a.r.u.l.A.z.a.h.a.r. Mohd Razali, D.e.w.i.K.u.m.a.r.a. Wati, M.o.y.S.i.e.w. Fong, R.e.v.a.t.h.y. Nallusamy, A.z.a.r. Kariminia, A.n.n.e.t.t.e.H. Sohn   +21 more
doaj   +1 more source

Physical activity and quality of life in adolescents and orphans

Exercise and Quality of Life, 2020
The aim of this study was to determine the relationship between physical activity and the quality of life in secondary school pupils and in orphans. The second aim was to determine differences in physical activity habits among groups.
Lucija Maglica, Hrvoje Karninčić, Ana Penjak, Gordan Drašinac   +3 more
doaj   +1 more source

Vietnam research situation analysis on orphans and other vulnerable children [PDF]

, 2009
This item is archived in the repository for materials published for the USAID supported Orphans and Vulnerable Children Comprehensive Action Research Project (OVC-CARE) at the Boston University Center for Global Health and Development.Addressing the ...
Beard, Jennifer, Biemba, Godfrey, Brooks, Bram, Costello, Jill, Ha, Le Hai, Nguyen, Huong T., Simon, Jonathon   +6 more
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Permasalahan yang Dihadapi oleh Anak Panti Asuhan di Kota Padang dan Implikasinya terhadap Pelayanan Bimbingan dan Konseling

Jurnal Konseling dan Pendidikan, 2014
Ideally, orphans that live in orphanage don’t have any trouble with the environment. In fact, orphans frequently coped with troubles in orphanage environment.
Venny Nilam Sari, Mudjiran Mudjiran, Yusri Yusri   +2 more
doaj   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

La tutela degli orfani nelle Leggi di Platone: una risposta alle aporie della prassi ateniese

Erga-Logoi, 2020
This paper addresses the guardianship of orphans in Plato’s Laws. The aim is to state whether the philosopher, through his theoretic model, wanted to correct the critical issues of the Athenian legal system that he perceived as most problematic.
Annabella Oranges
doaj   +1 more source

‘Once upon a time …’ Orphanhood, childhood studies and the depoliticisation of childhood poverty in southern Africa [PDF]

, 2015
Policy, interventions and research concerning southern African children remain dominated by a focus on AIDS-related orphanhood, although the association between orphanhood and disadvantage is highly questionable. I argue that the trope of the AIDS orphan
Ansell, N
core   +1 more source