Results 11 to 20 of about 81,520 (144)
A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin-4-one Analogues. [PDF]
ChemistryOpenQuinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Manhas N +4 more
europepmc +2 more sources
Angewandte Chemie, Volume 135, Issue 32, August 7, 2023., 2023 The asymmetric synthesis of trifluoromethylated propargylic ethers and amines is described. The reaction proceeds with high enantioselectivity using a simple chiral CuI‐BOX system and tolerates a broad range of alcohol, aniline and alkyne substitution. With chiral alcohols, a high diastereoselectivity is observed, indicating good catalyst stereocontrol.
Nieves P. Ramirez, Jerome Waser
wiley +2 more sources
Testing CPT symmetry in ortho-positronium decays with positronium annihilation tomography [PDF]
Nature Communications, 2021 Charged lepton system symmetry under combined charge, parity, and time-reversal transformation (CPT) remains scarcely tested. Despite stringent quantum-electrodynamic limits, discrepancies in predictions for the electron–positron bound state (positronium
P. Moskal +37 more
semanticscholar +1 more source
Photocleavable Ortho-Nitrobenzyl-Protected DNA Architectures and Their Applications
Chemical Reviews, 2023 This review article introduces mechanistic aspects and applications of photochemically deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on diverse research fields including DNA nanotechnology and materials chemistry ...
Michael P. O’Hagan +6 more
semanticscholar +1 more source
European Journal of Organic Chemistry, Volume 26, Issue 46, December 6, 2023., 2023 The multi‐step reduction of carboxy groups to methyl groups commonly used in organic synthesis is simplified by a new metal‐free catalyst system. It uses boronic acids to catalyze the single‐step reduction of esters, carboxylic acids and carbamates to methyl groups.
Xuewen Guo +3 more
wiley +1 more source
2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring
Nature Chemistry, 2023 The ortho -substituted phenyl ring is a basic structural element in chemistry. It is found in more than three hundred drugs and agrochemicals. During the past decade, scientists have tried to replace the phenyl ring in bioactive compounds with saturated ...
Aleksandr V. Denisenko +6 more
semanticscholar +1 more source
Synthetic Routes to Imidates and Their Applications in Organic Transformation: Recent Progress
European Journal of Organic Chemistry, Volume 26, Issue 39, October 16, 2023., 2023 Imidates are important organic intermediates used in several synthetic transformations towards N‐heterocycles, natural products and metal complexes with a potential catalytic effect. Herein, the recent synthetic approaches and diverse applications of imidates were categorized and summarized.
Andriani G. Chaidali, Ioannis N. Lykakis
wiley +1 more source
Adamantaniline Derivatives Target ATP5B to Inhibit Translation of Hypoxia Inducible Factor‐1α
Advanced Science, Volume 10, Issue 25, September 5, 2023., 2023 By means of high‐throughput screening, structure modification, and mechanism study, HI‐derivatives, containing an adamantaniline moiety are found, inhibiting hypoxia inducible factor‐1α (HIF‐1α) transcriptional activity by promoting the binding of HIF‐1α mRNA to ATP5B in a FoF1‐ATP synthase enzyme activity‐independent manner. The findings provide a new
Huiti Li +11 more
wiley +1 more source
Functionalized Cycloolefin Ligand as a Solution to Ortho-Constraint in the Catellani-Type Reaction.
Journal of the American Chemical Society, 2023 The Catellani reaction, i.e., the Pd/norbornene (NBE) catalysis, has been evolved into a versatile approach to multisubstituted arenes via the ortho-functionalization/ipso-termination process of a haloarene.
Feng-Yuan Wang, Yu-Xiu Li, L. Jiao
semanticscholar +1 more source
Hydrogen Atom Transfer from HOO. to ortho‐Quinones Explains the Antioxidant Activity of Polydopamine
Angewandte Chemie, 2021 Melanins are stable and non‐toxic biomaterials with a great potential as chemopreventive agents for diseases connected with oxidative stress, but the mechanism of their antioxidant action is unclear.
Yafang Guo +6 more
semanticscholar +1 more source