Results 31 to 40 of about 607,453 (284)

Orthogonal Projection and Total Least Squares [PDF]

open access: yesNumerical Linear Algebra with Applications, 1993
AbstractOverdetermined linear systems often arise in applications such as signal processing and modern communication. When the overdetermined system of linear equations AX ≈︁ B has no solution, compatibility may be restored by an orthogonal projection method. The idea is to determine an orthogonal projection matrix P by some method M such that [Ã B̃] =
Ricardo D. Fierro, James R. Bunch
openaire   +3 more sources

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Legendre polynomial order selection in projection pursuit density estimation

open access: yesLietuvos Matematikos Rinkinys, 2013
Projection pursuit method and its application to probability density estimation is discussed. Method proposed by J.H. Friedman, based on projection density estimation using orthogonal Legendre polynomials, is analysed.
Mindaugas Kavaliauskas
doaj   +1 more source

Orthogonal Spatial Domain Subspace Projection Based Time-Varying Channel Estimation

open access: yesIEEE Access, 2020
Time-varying channel estimation is a well-known challenge for the wireless communications in the high mobility environments. In this paper, we propose a basis expansion model (BEM) based channel estimation algorithm utilizing orthogonal spatial domain ...
Rong Zeng, Qiang Huang, Hao Wang
doaj   +1 more source

The Orthogonal Projection and the Riesz Representation Theorem [PDF]

open access: yesFormalized Mathematics, 2015
Abstract In this article, the orthogonal projection and the Riesz representation theorem are mainly formalized. In the first section, we defined the norm of elements on real Hilbert spaces, and defined Mizar functor RUSp2RNSp, real normed spaces as real Hilbert spaces.
Keiko Narita   +2 more
openaire   +4 more sources

The identities for generalized Fibonacci numbers via orthogonal projection [PDF]

open access: yes, 2019
In this paper, we consider the space R(p, 1) of generalized Fibonacci sequences and orthogonal bases of this space. Using these orthogonal bases, we obtain the orthogonal projection onto a subspace R(p, 1) of R-n.
Kocer, E. Gokcen, Alp, Yasemin
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Orthogonal Polynomials, Paraorthogonal Polynomials, and Point Perturbation [PDF]

open access: yes, 2009
This thesis consists of three parts. Part 1 starts with an introduction to orthogonal polynomials, to be followed by some well-known theorems pertinent to the results we shall discuss.
Wong, Manwah Lilian
core   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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