Results 51 to 60 of about 357,436 (278)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The generation method of orthophoto expansion map of arched dome mural based on three-dimensional fine color model

Heritage Science
Murals carry cultural significance and historical information, and are an important channel for understanding ancient social norms, artistic styles, and religious beliefs.
Chunmei Hu, Yang Wang, Guofang Xia, Yang Han, Xinjian Ma, Guofeng Jing   +5 more
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

A note on free divergence-free vector fields

Comptes Rendus. Mathématique
We exhibit an orthonormal basis of cyclic gradients and a (non-orthogonal) basis of the homogeneous free divergence-free vector field on the full Fock space and determine the dimension of Voiculescu’s free divergence-free vector field of degree $k$ or ...
Ito, Hyuga, Miyagawa, Akihiro
doaj   +1 more source

Orthogonal Neighborhood Preserving Projections [PDF]

Fifth IEEE International Conference on Data Mining (ICDM'05), 2006
Orthogonal neighborhood preserving projections (ONPP) is a linear dimensionality reduction technique which attempts to preserve both the intrinsic neighborhood geometry of the data samples and the global geometry. The proposed technique constructs a weighted data graph where the weights are constructed in a data-driven fashion, similarly to locally ...
E. Kokiopoulou, Y. Saad
openaire   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

METHOD FOR TEACHING GRAPHICAL REPRESENTATION OF PARTS IN TECHNICAL DRAWING

Journal of Industrial Design and Engineering Graphics, 2017
The paper presents applications meant to develop and improve the spatial ability of the students and to enable and develop their spatial perception of the objects.
Ramona Clinciu
doaj   +4 more sources

Three-by-three bound entanglement with general unextendible product bases

, 2011
We discuss the subject of Unextendible Product Bases with the orthogonality condition dropped and we prove that the lowest rank non-separable positive-partial-transpose states, i.e.
Harris J., Hartshorne R., Størmer E., Łukasz Skowronek   +3 more
core   +1 more source

Projective Spaces as Orthogonal Modular Varieties

Transformation Groups, 2022
We construct $16$ reflection groups $ $ acting on symmetric domains $\mathcal{D}$ of Cartan type IV, for which the graded algebras of modular forms are freely generated by forms of the same weight, and in particular the Satake--Baily--Borel compactification of $\mathcal{D} / $ is isomorphic to a projective space.
Haowu Wang, Brandon Williams
openaire   +4 more sources

Effect of Oxygen Content on Surface and Subsurface Integrity During Turning of Ti–6Al–4V

Advanced Engineering Materials, EarlyView.
This study examines how oxygen content in the ambient atmosphere affects the surface and subsurface properties of Ti–6Al–4V during turning. Results show that oxygen does not influence surface roughness. However, machining in an extremely high vacuum‐adequate atmosphere increases surface hardness by up to 7.8% and induces compressive residual stresses ...
Benjamin Bergmann, Berend Denkena, Hilke Petersen, Florian Schaper   +3 more
wiley   +1 more source