Results 51 to 60 of about 1,222,244 (245)

Sparse kernel density construction using orthogonal forward regression with leave-one-out test score and local regularization [PDF]

open access: yes, 2004
This paper presents an efficient construction algorithm for obtaining sparse kernel density estimates based on a regression approach that directly optimizes model generalization capability.
Harris, C. J.   +3 more
core   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Orthogonal learning particle swarm optimization [PDF]

open access: yes, 2010
Particle swarm optimization (PSO) relies on its learning strategy to guide its search direction. Traditionally, each particle utilizes its historical best experience and its neighborhood’s best experience through linear summation.
Zhi-hui Zhan   +7 more
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

open access: yesMolecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara   +10 more
wiley   +1 more source

ESTIMATION BY THE PICK FACTOR OF BROADBAND SIGNALS IN THE BASIS OF THE FUNNY LEGGER

open access: yesSučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2018
Recently, in a number of works devoted to the synthesis and processing of complex signals, along with the trigonometric basis, other orthogonal bases are also used.
Nikolai B. Nikulin, Igor V. Romashko
doaj  

Four Wave Mixing-Based Time Lens for Orthogonal Polarized Input Signals

open access: yesIEEE Photonics Journal, 2017
We present highly efficient time-lenses for orthogonal polarized signal waves with a specific state of polarization. Our four-wave mixing based time-lenses exploit polarization mode dispersion to compensate for chromatic dispersion.
Avi Klein   +4 more
doaj   +1 more source

Feedback communication using orthogonal signals [PDF]

open access: yesIEEE Transactions on Information Theory, 1969
We consider a feedback communication system in which the forward and feedback channels are disturbed by additive noise and constrained in average power. Two block coding schemes are proposed in which the signals are orthogonal waveforms. A finite number of forward and feedback transmissions per message is made.
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Harmful intrusion detection algorithm of optical fiber pre-warning system based on correlation of orthogonal polarization signals

open access: yesPhotonic Sensors, 2017
At present, advanced researches of optical fiber intrusion measurement are based on the constant false alarm rate (CFAR) algorithm. Although these conventional methods overcome the interference of non-stationary random signals, there are still a large ...
Fukun Bi   +4 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

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