Results 91 to 100 of about 3,847 (223)

Ecology of Neglected Rodent-Borne American Orthohantaviruses [PDF]

, 2020
The number of documented American orthohantaviruses has increased significantly over recent decades, but most fundamental research has remained focused on just two of them: Andes virus (ANDV) and Sin Nombre virus (SNV).
Forbes, Kristian M., Jackson, Reilly, Mull, Nathaniel, Sironen, Tarja   +3 more
core   +2 more sources

Seoul orthohantavirus evades innate immune activation in reservoir endothelial cells [PDF]

PLOS Pathogens
AbstractPathogenic hantaviruses are maintained world-wide within wild, asymptomatic rodent reservoir hosts, with increasingly frequent human spillover infections resulting in severe hemorrhagic fever disease. With no approved therapeutics or vaccines, research has, until recently, focused on understanding the drivers of immune-mediated pathogenesis. An
Stefan D. Klimaj, Autumn T. LaPointe, Kimberly Martinez, Eduardo Hernandez Acosta, Alison M. Kell   +4 more
openalex   +4 more sources

Molecular identification of Puumala orthohantavirus in Bulgaria

Infection, Genetics and Evolution, 2019
In Bulgaria, only Dobrava orthohantavirus has been detected in patients and in rodents. In order to elucidate possible Puumala orthohantavirus (PUUV) circulation, 131 bank voles (Myodes glareolus) were captured. PUUV RNA was detected in 14 (10.7%). Partial L segment sequences were recovered from six M. glareolus.
Iva Christova, Iva Trifonova, Elitsa Panayotova, Hristo Dimitrov, Teodora Gladnishka   +4 more
openaire   +3 more sources

Metagenomics screening of viruses in Arusha, north Tanzania: a one health perspective across wild rodents, domestic dogs and humans [PDF]

, 2023
Background: One of the most significant and perilous challenges faced by African societies, including Tanzania, is the public health threat posed by zoonotic viruses.
Chengula, Augustino, Issae, Amina, Kasanga, Christopher, Katakweba, Abdul Ahmed, Kicheleri, Rose   +4 more
core   +2 more sources

Andes Virus Genome Mutations That Are Likely Associated with Animal Model Attenuation and Human Person-to-Person Transmission

mSphere, 2023
We performed whole-genome sequencing with bait enrichment techniques to analyze Andes virus (ANDV), a cause of human hantavirus pulmonary syndrome.
Carla M. Bellomo, Daniel O. Alonso, Unai Pérez-Sautu, Karla Prieto, Sebastian Kehl, Rocio M. Coelho, Natalia Periolo, Nicholas Di Paola, Natalia Ferressini-Gerpe, Jens H. Kuhn, Mariano Sanchez-Lockhart, Gustavo Palacios, Valeria P. Martínez   +12 more
doaj   +1 more source

Comparison of Lymphocyte Populations in Patients With Dobrava or Puumala orthohantavirus Infection [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Hemorrhagic fever with renal syndrome (HFRS), caused by Dobrava (DOBV) and Puumala (PUUV) orthohantaviruses, is an endemic disease in Slovenia. DOBV is mainly responsible for a more severe disease, whereas PUUV usually causes a milder form. Therefore, the aim of our study was to determine whether any differences in lymphocyte population in patients ...
Andreja Nataša Kopitar, Miroslav Petrovec, Miša Korva, Katarina Resman Rus, Alojz Ihan, Tatjana Avšič-Županc   +5 more
openaire   +4 more sources

Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations [PDF]

Viruses, 2021
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host–pathogen complex ...
Sabrina Schmidt, Daniela Reil, Kathrin Jeske, Stephan Drewes, Ulrike M. Rosenfeld, Stefan Fischer, Nastasja G. Spierling, Anton Labutin, Gerald Heckel, Jens Jacob, Rainer G. Ulrich, Christian Imholt   +11 more
openaire   +6 more sources

In Vitro Anti-Orthohantavirus Activity of the High-and Low-Molecular-Weight Fractions of Fucoidan from the Brown Alga Fucus evanescens

Marine Drugs, 2021
The Hantaan orthohantavirus (genovariant Amur–AMRV) is a rodent-borne zoonotic virus; it is the causative agent of haemorrhagic fever with renal syndrome in humans.
Natalia V. Krylova, Artem S. Silchenko, Anastasia B. Pott, Svetlana P. Ermakova, Olga V. Iunikhina, Anton B. Rasin, Galina G. Kompanets, Galina N. Likhatskaya, Mikhail Y. Shchelkanov   +8 more
doaj   +1 more source

Dissection of the NKG2C NK cell response against Puumala Orthohantavirus

PLOS Neglected Tropical Diseases, 2021
Background Infections with the Puumala orthohantavirus (PUUV) in humans may cause hemorrhagic fever with renal syndrome (HFRS), known as nephropathia epidemica (NE), which is associated with acute renal failure in severe cases. In response to PUUV-infections, a subset of potent antiviral NKG2C+ NK cells expand, whose role in virus defence and ...
Hannes Vietzen, Svenja Hartenberger, Stephan W. Aberle, Elisabeth Puchhammer-Stöckl   +3 more
openaire   +4 more sources

Genetic diversity and phylogeography of Jeju Orthohantavirus (Hantaviridae) in the Republic of Korea

Virology, 2020
Orthohantaviruses are negative-sense, single-stranded RNA viruses harbored by rodents, shrews, moles, and bats. Of the shrew-borne orthohantaviruses in the Republic of Korea (ROK), Jeju orthohantavirus (Jeju virus, JJUV) was found on Jeju Island. This small-scale epidemiologic survey investigated the geographic distribution and molecular phylogeny of ...
Seung‐Ho Lee, Won‐Keun Kim, Kyungmin Park, Jin Sun No, Geum-Young Lee, Heung-Chul Kim, Terry A. Klein, Mi-Sook Min, Seo‐Jin Lee, Jusun Hwang, Man‐Seong Park, Jin‐Won Song   +11 more
openalex   +3 more sources