Results 81 to 90 of about 250,488 (295)

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Patients with Clinically Suspected but Unproven Hip Fractures, Who Require Cross-Sectional Imaging, Are Best Initially Admitted under Geriatrician-Led Care—A Retrospective Review

Geriatrics, 2018
Patients with suspected hip fractures who require further imaging to confirm or disprove the diagnosis may be admitted to orthopaedic or medical departments. We aim to provide evidence regarding the appropriate admission pathway for such patients.
Hamish Macdonald, Niraj Vetharajan, Peter Kempshall   +2 more
doaj   +1 more source

Non-invasive computer-assisted measurement of knee alignment [PDF]

, 2012
The quantification of knee alignment is a routine part of orthopaedic practice and is important for monitoring disease progression, planning interventional strategies, and follow-up of patients.
Angela H. Deakin, Bargren JH, Frederic Picard, Jon V. Clarke, Krackow KA, Markolf KL, Philip E. Riches, Picard F, Stulberg DS, Wasielewski RC   +9 more
core   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

The Impact of Attention-Deficit/Hyperactivity Disorder on Postoperative Orthopedic Complications in Total Shoulder Arthroplasty: A Retrospective Cohort Study

The Hive
Background: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by impulsiveness and challenges with adherence, potentially affecting surgical outcomes.
Seyedeh Zahra Mousavi, Mahdieh Saeidi, Henry M. Fox, Sasidhar Gunturu , Umasuthan Srikumaran   +4 more
doaj   +1 more source

CAD, CAE and rapid prototyping methods applied in long bones orthopaedics [PDF]

FME Transactions, 2019
The paper presents some methods used to analyze human bone joints. First, there were defined the 'hard' parts as the main bone components and 'soft' parts as ligaments or menisci using CT images.
Popa Dragos-Laurentiu, Buciu G., Calin D.C., Popkonstantinović B., Poenaru F.   +4 more
doaj  

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Supplementum 269: Abstracts of the 83th annual meeting of swiss orthopaedics

Swiss Medical Weekly, 2023
swiss orthopaedics
doaj   +1 more source

Current update on surgical management for spinal tuberculosis: a scientific mapping of worldwide publications

Frontiers in Surgery
IntroductionSpinal tuberculosis (TB), or Pott's disease, remains a significant global health issue, particularly in regions with high TB prevalence. Despite antitubercular drug therapy being the primary treatment, surgical intervention is often required ...
Romaniyanto Romaniyanto, Muhana Fawwazy Ilyas, Aldebaran Lado, Daffa Sadewa, Daffa Sadewa, Dykall Naf'an Dzikri, Enrico Ananda Budiono, Enrico Ananda Budiono   +7 more
doaj   +1 more source

The Contributions of Kenelm Hutchinson Digby to Orthopaedics in Hong Kong Part 2

Journal of Orthopaedics, Trauma and Rehabilitation, 2016
As the first professor of surgery in Hong Kong, Kenelm Hutchinson Digby had the tremendous task of building a new clinical department in the infant University of Hong Kong from scratch.
Kuo-tai Louis Fu
doaj   +1 more source