Results 71 to 80 of about 224,709 (317)

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Dynamics of Bone Trap-5b Level in Patients with Bone Metastases of Renal Cell Cancer at Combined Treatment [PDF]

, 2017
The objective of this study was to determine the sensitivity of tartrate-resistant acid phosphatase (Bone TRAP-5b) for early detection of bone metastases (BM) and to investigate the efficacy of bisphosphonates (BF) (zolendronic acid-ZA) in prevention of ...
Boichuk, S. (Serhiy), Diedkov, A. (Anatoliy), Kostiuk, V. (Viktor), Ostafiychuk, V. (Vasyliy)   +3 more
core   +2 more sources

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

Advanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi, Claudia Corbo, Julia Enterria‐Rosales, John Otto Martinez, Silvia Minardi, Laura Pandolfi, Xing Wang, Ennio Tasciotti, Kavindra V. Singh, Cesar A. Arias, Bruna Corradetti   +10 more
wiley   +1 more source

Closing the Calibration Loop: An Inside-out-tracking Paradigm for Augmented Reality in Orthopedic Surgery [PDF]

arXiv, 2018
In percutaneous orthopedic interventions the surgeon attempts to reduce and fixate fractures in bony structures. The complexity of these interventions arises when the surgeon performs the challenging task of navigating surgical tools percutaneously only under the guidance of 2D interventional X-ray imaging. Moreover, the intra-operatively acquired data
arxiv  

Cephalometric variability among siblings [PDF]

, 2019
OBJECTIVE: To determine whether multiple siblings in a family resemble one another in terms of their craniofacial characteristics.  METHODS: This pilot study was conducted retrospectively using the Forsyth Twin sample.
Marcks, Katharine Luskin
core  

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Common injuries in athletes' knee: experience of a specialized center [PDF]

, 2014
OBJECTIVE:The present cross-sectional study aims to identify the most common knee injuries in athletes cared at a Specialized Outpatient Clinics.METHOD:Analysis of patients cared at the Knee Outpatient Clinics of a Sports Trauma Center, divided by gender,
Carvalho, Rogerio Teixeira de, Cohen, Moises, Matsuda, Marcelo Mitsuro, Nicolini, Alexandre Pedro, Sayum Filho, Jorge   +4 more
core   +1 more source

Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived apoptotic bodies (MSC‐ABs) target keloid fibroblasts (KFs), restoring nicotinamide adenine dinucleotide (NAD) metabolism and mitochondrial function, suppressing collagen overproduction, and rebalancing tissue homeostasis, offering a novel therapy for keloid.
Shutong Qian, Siya Dai, Chunyi Guo, Wenjun Wang, Jiajia Pang, Yichen Shen, Mingyuan Xu, Jie Hu, Wenguo Cui, Xiaoming Sun, Jinghong Xu   +10 more
wiley   +1 more source

Endoprosthesis vs. nail-cement spacer application for reconstruction after oncologic proximal humeral resection: is there a difference in functional outcome?

JSES International
Background: The proximal humerus is a common site for primary malignant and benign aggressive bone tumors, necessitating wide resection and subsequent skeletal defect reconstruction.
Sandeep Sehrawat, MS (Orthopedics), Abhijit Behera, MS (Orthopedics), Love Kapoor, MS (Orthopedics), Venkatesan Sampath Kumar, MS (Orthopedics), DNB (Orthopedics), MRCS, FRCS (Tr & Orth Glasg), Sameer Bakhshi, MD, DM (Medical Oncology), Shah Alam Khan, MS (Orthopedics), DNB (Orthopedics), MRCS (Edi), MChOrth (Liverpool)   +5 more
doaj  

USE OF LASER IN MEDICINE, POTENTIAL OF USING LASER ERADIATION IN TRAUMATOLOGY AND ORTHOPEDICS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
The aim of the present article is to analyze foreign and native literature sources devoted to the effect of laser eradiation on biological tissue. The paper describes the potential of using laser in traumatology and orthopedics, which can optimize and ...
Khotim O. A., Anosov V. S., Sychevskiy L. Z.   +2 more
doaj   +1 more source