Results 81 to 90 of about 250,849 (291)
Advanced Science, EarlyView.The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen +11 more
wiley +1 more source
From Ejtm (European Journal of Translational Myology) to Ejt3M (European Journal of Translational Myology, Mobility, Medicine) [PDF]
, 2018 This first 2018 issue of the European Journal of Translational Myology presents many novelties, that demonstrate that the journal is vital and expanding its authorship, readership and relevance from focused fields of biology, physiology, diagnostic ...
Adamo, Sergio
core +2 more sources
Advanced Science, EarlyView.TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng +9 more
wiley +1 more source
Treatment Strategies for Distal Clavicle Fractures: A Narrative Review
Orthopedic Research and ReviewsLei Yue,* Changsheng Huang,* Jianming Zhang, Ziqi Wang, Shijun Wang, Haolin Sun Department of Orthopedics, Peking University First Hospital, Beijing, People’s Republic of China*These authors contributed equally to this ...
Yue L +5 more
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Surgical technique: Tscherne-Johnson extensile approach for tibial plateau fractures. [PDF]
, 2013 BackgroundThe standard approach to lateral tibial plateau fractures involves elevation of the iliotibial band (IT) and anterior tibialis origin in continuity from Gerdy's tubercle and metaphyseal flare.
Johnson, Eric E +2 more
core +1 more source
Advanced Science, EarlyView.Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu +11 more
wiley +1 more source
Clinical EpidemiologyZhongjiang Lan,1,2,* Le Zhou,3,4,* Yanliang Jiao,1,2 Shihu Kan,1,2 Songxiahe Zhao,1,2 Lei Chen,1,2 Yibin Du1 1Department of Orthopedics, The Third Affiliated Hospital of Anhui Medical University (The First People’s Hospital of Hefei ...
Lan Z +6 more
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Hydrogen Peroxide Wound Irrigation in Orthopaedic Surgery. [PDF]
, 2017 As the burden of deep hardware infections continues to rise in orthopaedics, there is increasing interest in strategies for more effective debridement of colonized tissues and biofilm.
Hansen, Erik Nathan, Lu, Min
core +1 more source
Advanced Science, EarlyView.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Local and Regional AnesthesiaGuiyu Lei,1 Lili Wu,1 Yue Yin,1 Shu Zhang,2 Guyan Wang1 1Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, People’s Republic of China; 2Center of Foot and Ankle Surgery, Beijing Tongren Hospital, Capital
Lei G, Wu L, Yin Y, Zhang S, Wang G
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