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Orthopoxvirus infection among wildlife in Zambia
Journal of General Virology, 2015(Uploaded by Plazi for the Bat Literature Project) Human monkeypox is a viral zoonosis caused by monkeypox virus, an orthopoxvirus (OPXV). The majority of human monkeypox cases have been reported in moist forested regions in West and Central Africa, particularly in the Democratic Republic of the Congo (DRC).
Orba, Yasuko +10 more
openaire +5 more sources
2004
Biologic and antigenic properties are often useful for identifying and differentiating orthopoxviruses (OPV). However, polymerase chain reaction (PCR) amplification, with either restriction cleavage or sequencing of amplicons, has been gaining credibility as a more rapid, specific, sensitive, and often cost-saving technique for research and diagnostic ...
Hermann, Meyer +2 more
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Biologic and antigenic properties are often useful for identifying and differentiating orthopoxviruses (OPV). However, polymerase chain reaction (PCR) amplification, with either restriction cleavage or sequencing of amplicons, has been gaining credibility as a more rapid, specific, sensitive, and often cost-saving technique for research and diagnostic ...
Hermann, Meyer +2 more
openaire +2 more sources
1990
Genetic analysis of orthopoxviruses has contributed substantially to our understanding of the functional organization of the poxvirus genome, and individual mutants provide invaluable tools for future studies of poxvirus biology. Deletion and transposition mutants, localized primarily in the termini of the genome, may be particularly useful for ...
R C, Condit, E G, Niles
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Genetic analysis of orthopoxviruses has contributed substantially to our understanding of the functional organization of the poxvirus genome, and individual mutants provide invaluable tools for future studies of poxvirus biology. Deletion and transposition mutants, localized primarily in the termini of the genome, may be particularly useful for ...
R C, Condit, E G, Niles
openaire +2 more sources
ChemMedChem, 2022
In this work, a library of (+)‐camphor and (−)‐fenchone based N‐acylhydrazones, amides, and esters, including para‐substituted aromatic/hetaromatic/cyclohexane ring was synthesized, with potent orthopoxvirus inhibitors identified among them ...
A. Sokolova +15 more
semanticscholar +1 more source
In this work, a library of (+)‐camphor and (−)‐fenchone based N‐acylhydrazones, amides, and esters, including para‐substituted aromatic/hetaromatic/cyclohexane ring was synthesized, with potent orthopoxvirus inhibitors identified among them ...
A. Sokolova +15 more
semanticscholar +1 more source
Orthopoxvirus pan-genomic DNA assay
Journal of Virological Methods, 2007A genome-spanning assay is described that enables laboratory confirmation of infections with orthopoxviruses (OPVs), particularly Vaccinia, Monkeypox, and Variola viruses, which can cause vesiculo-pustular rash illnesses in humans. The assay uses a series of polymerase chain reaction (PCR) amplicons that overlap to span the approximately 200kilobase ...
Hui Zhao +4 more
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Biosecurity Implications for the Synthesis of Horsepox, an Orthopoxvirus
Health Security, 2017This article examines the biosecurity and biodefense implications resulting from the recent creation of horsepox virus, a noncirculating (extinct) species of orthopoxvirus. Here we examine the technical aspects of the horsepox virus synthesis and conclude that orthopox synthesis experiments currently remain technically challenging-and will continue to ...
Diane DiEuliis +2 more
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Orthopoxvirus vaccines and vaccination [PDF]
, 2007 Immunization procedures against Variola virus, from the historical perspective most often first credited to Edward Jenner in the late 18th century, helped finally to eradicate smallpox from the world. Since its eradication, the study of this disease and its pathology has been given little attention; however, with the emergence of Monkeypox virus into ...
Clifford J. Bellone +3 more
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Animal Models of Orthopoxvirus Infection
Veterinary Pathology, 2010Smallpox was one of the most devastating diseases known to humanity. Although smallpox was eradicated through a historically successful vaccination campaign, there is concern in the global community that either Variola virus (VARV), the causative agent of smallpox, or another species of Orthopoxvirus could be used as agents of bioterrorism. Therefore,
J. W. Raymond +3 more
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Inactivation of orthopoxvirus for diagnostic PCR analysis
Journal of Virological Methods, 2007Diagnoses of ongoing viral infections commonly rely on PCR methodology. Sample material that may contain hazardous virus should be efficiently inactivated in biological containment or bed-side before diagnostic PCR analysis. Surprisingly little documentation is available for inactivation of human viral pathogens by inactivation reagents that allow for ...
Anders Fomsgaard, Lasse Vinner
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Two types of deletions in orthopoxvirus genomes
Virus Genes, 1995The genome nucleotide sequences of two strains of variola major virus and one strain of vaccinia virus were compared. One hundred and sixty-eight short (less than 100 bp in length) and eight long (more than 900 bp in length) deletions, four deletion/insertion regions, and four regions of multiple mutational differences between variola and vaccinia ...
Totmenin Av, Sergei N. Shchelkunov
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