Results 271 to 280 of about 11,818 (284)
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The mechanism of cytoplasmic orthopoxvirus DNA replication
Cell, 1981Orthopoxvirus DNA replication occurs in the cytoplasm of infected cells within discrete foci designated as virosomes. We show that newly synthesized rabbit poxvirus (RPV) virosomal DNA consists predominantly of concatamers wherein unit length molecules are joined by fusion of two left (LL) or right (RR) ends, resulting in genomes aligned in alternating
Ramona L. Graves, Richard W. Moyer
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Antibodies to orthopoxvirus in domestic cats in Norway
Veterinary Record, 1998The prevalence of antibodies to orthopoxvirus in 217 sera collected from domestic cats in the western part of Norway was 10.1 per cent as measured by a competitive ELISA. In one of the seropositive cats antibodies were also detected by an immunofluorescence assay.
Morten Tryland +5 more
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Regulation of Orthopoxvirus Gene Expression
1990Poxviruses differ from the other major groups of DNA viruses with regard to their use of the cytoplasm, rather than the nucleus, as the site of transcription. Consistent with this strategy, poxviruses encode their own DNA-dependent RNA polymerase as well as many—if not all—of the additional enzymes and factors needed to synthesize functional capped ...
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Genus Orthopoxvirus: Monkeypox virus
2007Monkeypox virus is an orthopoxvirus that is genetically distinct from other members of the genus, including Variola virus, Vaccinia virus, Ectromelia virus, Camelpox virus, and Cowpox virus. It was first identified as the cause of a pox-like illness in captive monkeys in 1958.
Sandra Essbauer, Hermann Meyer
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Genus Orthopoxvirus: Cowpox virus
2007Cowpox virus (CPXV) is distinguished from other orthopoxvirus (OPV) species by producing cytoplasmic A-type inclusion bodies and flattened pocks with a hemorrhagic center on the chorioallantoic membrane. CPXV is endemic to Western Eurasia and naturally infects a broad range of host species including domestic animals, and zoo animals, as well as humans.
Hermann Meyer, Sandra Essbauer
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Skin lesions caused by orthopoxvirus infection in a dog
Journal of Small Animal Practice, 1999A seven‐year‐old male dobermann was presented for examination of a non‐pruritic ulcerated lesion occurring at the site of a suspected rat bite on the muzzle. Biopsy revealed focal ulcerative dermatitis, with cells in the epidermis, follicular infundibula and interposed sebaceous glands undergoing ballooning degeneration and containing large acidophilic
Malcolm J. Bennett +2 more
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Mouse Models for Studying Orthopoxvirus Respiratory Infections
2004Concern regarding the use of variola and monkeypox viruses as bioterrorist agents has led to an increased study of orthopoxviruses to understand the molecular and cellular basis of pathogenesis and develop safe and effective antivirals and vaccines against smallpox.
R. Mark L. Buller +2 more
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Preliminary Screening and In Vitro Confirmation of Orthopoxvirus Antivirals
2019The lack of antiviral drugs for the treatment of orthopoxvirus disease represents an unmet medical need, particularly due to the threat of variola virus (the causative agent of smallpox) as an agent of biowarfare or bioterrorism (Henderson, 283:1279-1282, 1999).
Douglas W. Grosenbach, Dennis E. Hruby
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Orthopoxvirus Purification for High Containment Laboratories
Purification of large viruses in a high containment laboratory can create unique challenges. Traditional purification methods for large viruses rely on equipment and techniques that are not ideal for high containment work. Poxvirus purification has long relied on the use of Genetron®, a reagent that is no longer available.Laura, Hughes +4 more
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Genus Orthopoxvirus: Variola virus
2007Variola major virus caused the human disease smallpox; interpretations of the historic record indicate that the initial introduction of disease in a naive population had profound effects on its demographics. Smallpox was declared eradicated by the World Health Organization (WHO) in 1980.
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