Mechanism of action of Orthosiphon stamineus against non-alcoholic fatty liver disease: Insights from systems pharmacology and molecular docking approaches [PDF]
Saudi Pharmaceutical Journal, 2022 Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of a metabolic syndrome caused by excessive accumulation of fat in the liver.
Salah Abdulrazak Alshehade +5 more
doaj +2 more sources
A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications [PDF]
Molecules, 2022 (1) Background: Orthosiphon stamineus Benth. is a traditional medicine used in the treatment of diabetes and chronic renal failure in southern China, Malaysia, and Thailand.
Qirou Wang +6 more
doaj +2 more sources
Polymolecular botanical drug of Orthosiphon stamineus extract (C5OSEW5050ESA) as a complementary therapy to overcome gemcitabine resistance in pancreatic cancer cells [PDF]
Journal of Traditional and Complementary Medicine, 2023 Background and aim: Gemcitabine remains the cornerstone of pancreatic cancer treatment, despite exhibiting a modest effect on patient survival due to the development of drug resistance.
Ashwaq H.S. Yehya +3 more
doaj +2 more sources
In Vivo and In Vitro Antidiabetic Efficacy of Aqueous and Methanolic Extracts of Orthosiphon Stamineus Benth [PDF]
Pharmaceutics, 2023 Orthosiphon stamineus is a popular folk herb used to treat diabetes and some other disorders. Previous studies have shown that O. stamineus extracts were able to balance blood glucose levels in diabetic rat animal models.
Najlaa Bassalat +8 more
doaj +2 more sources
Analysis of the chemical constituents and their metabolites in Orthosiphon stamineus Benth. via UHPLC-Q exactive orbitrap-HRMS and AFADESI-MSI techniques. [PDF]
PLoS ONEBackgroundKnown for its strong diuretic properties, the perennial herbaceous plant Orthosiphon stamineus Benth. is believed to preserve the kidney disease. This study compared the boiling water extract with powdered Orthosiphon stamineus Benth.
Jianting Ouyang +13 more
doaj +2 more sources
Journal of Pharmacy and Bioallied Sciences, 2021 Background: Orthosiphon stamineus was reported to have diuretic effects in experimental rats, and this leads to inhibition of kidney stones through the abundant levels of minerals and flavonoids in it.
Muhammad Bala Ambursa +7 more
doaj +2 more sources
Antioxidant and toxicity studies of 50% methanolic extract of Orthosiphon stamineus Benth. [PDF]
Biomed Res Int, 2013 The present study evaluated the antioxidant activity and potential toxicity of 50% methanolic extract of Orthosiphon stamineus (Lamiaceae) leaves (MEOS) after acute and subchronic administration in rats.
Yam MF +8 more
europepmc +8 more sources
Toxicological studies of Orthosiphon stamineus (Misai Kucing) standardized ethanol extract in combination with gemcitabine in athymic nude mice model [PDF]
Journal of Advanced Research, 2019 Pancreatic cancer has the highest mortality rate among cancers due to its aggressive biology and lack of effective treatment. Gemcitabine, the first line anticancer drug has reduced efficacy due to acquired resistance.
Ashwaq H.S. Yehya +6 more
doaj +2 more sources
Orthosiphon stamineus Standardized Extract Reverses Streptozotocin-Induced Alzheimer’s Disease-Like Condition in a Rat Model [PDF]
Biomedicines, 2020 Alzheimer’s disease (AD) is a chronic neurodegenerative brain disease that is characterized by impairment in cognitive functioning as well as the presence of intraneuronal neurofibrillary tangles (NFTs) and extracellular senile plaques.
Thaarvena Retinasamy +4 more
doaj +2 more sources
Preparation and characterization of nano liposomes of Orthosiphon stamineus ethanolic extract in soybean phospholipids. [PDF]
BMC Biotechnol, 2014 BACKGROUND: O. stamineus is a medicinal herb with remarkable pharmacological properties. However, poor solubility of the active principles limits its medicinal value.
Aisha AF, Majid AM, Ismail Z.
europepmc +2 more sources